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NCT04383665 · ClinicalTrials.gov registry record · NA
Low Frequency Subthalamic Nucleus Deep Brain Stimulation to Improve Verbal Fluency
A NA study, sponsored by University of Southern California.
- Completed
- Registry status
- NA
- Development phase
- 12
- Enrollment target
NCT04383665: Completed NA study, sponsored by University of Southern California.
NCT04383665 is a NA study that has completed, run by University of Southern California. The registered enrollment target is 12 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04383665, a NA study, has completed, sponsored by University of Southern California.
- COMPLETED
- Registry status
- NA
- Development phase
- 12 participants
- Enrollment target
Study Summary
Rationale: Parkinson's disease patients with deep brain stimulation electrodes represent a unique opportunity to study the influence of basal ganglia on neurocognitive function. Intervention: Patients' deep brain stimulators will be turned off or on and the frequency will be changed to either theta or gamma. Objectives: To identify differences in higher cognitive functions with stimulation "on" and "off" and theta versus gamma frequency stimulation. Study population: 12 patients who had previously undergone bilateral STN deep brain stimulation implantation. Study methodology: Patients will undergo four sessions of neuropsychological testing (RNGT, verbal fluency, D-KEFS CWIT) at baseline, no stimulation, theta stimulation and gamma stimulation, in random order over one day. Study outcomes: Test results of RNGT, verbal fluency, D-KEFS CWIT. Follow-up: none Statistics: Test results will be analyzed using within-subjects statistical tests.
Primary Outcome
Number of words per category in one minute
Interventions
- DEVICE STN DBS 10Hz
- DEVICE STN DBS 130Hz
- DEVICE STN DBS off
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 12 participants |
| Start Date | 2020-01-31 |
| Est. Completion | 2020-03-03 |
| Phase | NA |
What the finished NCT04383665 record still lists
NCT04383665 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 12 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower).
The record links to 0 conditions, and to 3 interventions - of which STN DBS 10Hz is the first listed.
NCT04383665 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04383665 about?
NCT04383665 is a clinical study titled "Low Frequency Subthalamic Nucleus Deep Brain Stimulation to Improve Verbal Fluency". Rationale: Parkinson's disease patients with deep brain stimulation electrodes represent a unique opportunity to study the influence of basal ganglia on neurocognitive function. Intervention: Patients' deep brain stimulators will be turned off or on and the frequency will be changed to either theta...
What is the current status of trial NCT04383665?
This trial is currently completed. It is a NA study. The enrollment target is 12 participants. The study started on 2020-01-31. Estimated completion is 2020-03-03.
What interventions are being tested in trial NCT04383665?
The interventions under investigation include: STN DBS 10Hz (DEVICE), STN DBS 130Hz (DEVICE), STN DBS off (DEVICE).
Who is sponsoring clinical trial NCT04383665?
This trial is sponsored by University of Southern California, which has 617 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT04383665's enrollment target sits among peer trials
12 1913th of 2000 higher than 74 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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