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NCT04374149 · ClinicalTrials.gov registry record · Phase 2
Therapeutic Plasma Exchange Alone or in Combination With Ruxolitinib in COVID-19 Associated CRS
A Phase 2 study, sponsored by Prisma Health-Upstate.
- Completed
- Registry status
- Phase 2
- Development phase
- 20
- Enrollment target
NCT04374149: Completed Phase 2 study, sponsored by Prisma Health-Upstate.
NCT04374149 is a Phase 2 study that has completed, run by Prisma Health-Upstate. The registered enrollment target is 20 participants, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (85% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04374149, a Phase 2 study, has completed, sponsored by Prisma Health-Upstate.
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 20 participants
- Enrollment target
Study Summary
This protocol will evaluate the efficacy of Therapeutic Plasma Exchange (TPE) alone or in combination with ruxolitinib in COVID positive patients with PENN grade 2, 3, 4 cytokine release syndrome (CRS). It is hypothesized that dual intervention of acute apheretic depletion of cytokines and concomitant suppression of production will produce superior amelioration of the cytokine load and to help to prevent cytokine load rebound. This protocol is envisioned as a pilot study (n=20) for hypothesis generation for future investigation.
Primary Outcome
Defined as decreasing the CRP level from baseline to study day 14
Interventions
- DRUG Ruxolitinib
- PROCEDURE Therapeutic Plasma Exchange
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 20 participants |
| Start Date | 2020-04-30 |
| Est. Completion | 2020-12-01 |
| Phase | Phase 2 |
What the finished NCT04374149 record still lists
NCT04374149 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 20 participants, a relatively small participant target, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (85% lower).
The record links to 0 conditions, and to 2 interventions - of which Ruxolitinib is the first listed.
NCT04374149 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04374149 about?
NCT04374149 is a clinical study titled "Therapeutic Plasma Exchange Alone or in Combination With Ruxolitinib in COVID-19 Associated CRS". This protocol will evaluate the efficacy of Therapeutic Plasma Exchange (TPE) alone or in combination with ruxolitinib in COVID positive patients with PENN grade 2, 3, 4 cytokine release syndrome (CRS). It is hypothesized that dual intervention of acute apheretic depletion of cytokines and concomita...
What is the current status of trial NCT04374149?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 20 participants. The study started on 2020-04-30. Estimated completion is 2020-12-01.
What interventions are being tested in trial NCT04374149?
The interventions under investigation include: Ruxolitinib (DRUG), Therapeutic Plasma Exchange (PROCEDURE).
Who is sponsoring clinical trial NCT04374149?
This trial is sponsored by Prisma Health-Upstate, which has 67 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT04374149's enrollment target sits among peer trials
20 1805th of 2000 higher than 107 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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