Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT04348591 · ClinicalTrials.gov registry record · NA
Identifying the Optimal Neural Target for Misophonia Interventions
A NA study of Misophonia and Emotion Dysregulation, sponsored by Duke University.
- Completed
- Registry status
- NA
- Development phase
- 59
- Enrollment target
- 1
- Study location
NCT04348591 is a NA study of Misophonia and Emotion Dysregulation that has completed, run by Duke University. The registered enrollment target is 59 participants, above the 50-participant average among 7 other Misophonia trials with a reported enrollment target (18% higher). The trial reports 1 study location across 1 state.
The verdict
NCT04348591, a NA study of Misophonia and Emotion Dysregulation, has completed, sponsored by Duke University.
- COMPLETED
- Registry status
- NA
- Development phase
- 59 participants
- Enrollment target
- 1
- Study location
Study Summary
Misophonia, the inability to tolerate certain repetitive aversive sounds that are common, is gaining recognition as a debilitating condition. It is not a well-understood condition and there are no known treatments. Up to one in five people report moderate or higher misophonia symptoms; nevertheless, resources aimed at understanding and treating this problem are scarce. In order to align misophonia research with the priorities of large funding agencies such as the National Institute of Mental Health, the investigators propose a novel study aimed at separating misophonic distress from other types of emotional distress. The investigators plan to examine changes in brain activation during presentation and regulation of misophonic versus distressing sounds. Emergent neural networks that may be involved in misophonia will then be tested in the lab with the use of noninvasive neurostimulation, a novel tool that can enhance or inhibit activation in a targeted brain region. The investigators plan to modulate activation in key areas of the misophonia brain circuitry with the aim to identify the optimal neural target for misophonia interventions. Our multidisciplinary team at the Duke Center for Misophonia and Emotion Regulation brings together experts in misophonia, neuroscience, neuromodulation, neurology, and biostatistics who share the long-term goal of developing and refining an intervention for this condition in an environment that is optimal to conduct the proposed research. The investigators propose to recruit adults who self-report significant misophonia symptoms and adults who meet criteria for a current psychiatric disorder and who self-report difficulties calming down when upset. All participants will undergo a brain imaging session during which misophonic cues; distressing, non-misophonic cues; or neutral cues will be presented. Participants will then be asked to experience, or attempt to downregulate emotions associated with these cues. Based on the imaging resu
Conditions Studied
Interventions
- BEHAVIORAL Cognitive Restructuring
- DEVICE neurostimulation
Study Locations (1)
North Carolina
- Duke University Medical Center-Civitan Bldg - Durham
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 59 participants |
| Start Date | 2020-10-28 |
| Est. Completion | 2022-05-28 |
| Phase | NA |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04348591
The ClinicalTrials.gov registry entry for NCT04348591 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 59 participants, a figure that helps gauge the scale of data the investigators plan to collect, above the 50-participant average among 7 other Misophonia trials with a reported enrollment target (18% higher). The listed sponsor is Duke University, which has 1,725 total studies on file at ClinicalTrials.gov.
The record links to 2 conditions, with Misophonia appearing as the primary indexed condition, and to 2 interventions - of which Cognitive Restructuring is the first listed.
NCT04348591 reports 1 study location spanning 1 distinct geographic area - top geographies include North Carolina.
Frequently Asked Questions
What is clinical trial NCT04348591 about?
NCT04348591 is a clinical study titled "Identifying the Optimal Neural Target for Misophonia Interventions". Misophonia, the inability to tolerate certain repetitive aversive sounds that are common, is gaining recognition as a debilitating condition. It is not a well-understood condition and there are no known treatments. Up to one in five people report moderate or higher misophonia symptoms; nevertheless,...
What is the current status of trial NCT04348591?
This trial is currently completed. It is a NA study. The enrollment target is 59 participants. The study started on 2020-10-28. Estimated completion is 2022-05-28.
What conditions does trial NCT04348591 study?
This clinical trial studies the following conditions: Misophonia, Emotion Dysregulation.
What interventions are being tested in trial NCT04348591?
The interventions under investigation include: Cognitive Restructuring (BEHAVIORAL), neurostimulation (DEVICE).
Who is sponsoring clinical trial NCT04348591?
This trial is sponsored by Duke University, which has 1,725 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04348591 being conducted?
This trial has 1 study location across North Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Misophonia
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
-
Using Neurostimulation to Accelerate Change in Misophonia: a Pilot Study
RECRUITING · NA
-
Transcranial Magnetic Stimulation in Misophonia
RECRUITING · NA
-
Mindfulness Application Effects on Mental Health Symptoms in Children With Severe Tinnitus and Misophonia
RECRUITING · NA
-
Digital Intervention for Adults With Misophonia: A Randomized Controlled Trial
RECRUITING · NA
-
Psychological Intervention for Misophonia
ACTIVE NOT RECRUITING · NA
-
Exploring the Acceptability and Efficacy of a Transdiagnostic Treatment for Misophonia
COMPLETED · NA
Explore more on PlainTrial
Read our methodology - how this data is sourced, computed, and verified.
Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.