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NCT04332523 · ClinicalTrials.gov registry record · Phase 1
A Study of JNJ-53718678 in Participants With Hepatic Impairment
A Phase 1 study, sponsored by Janssen Research & Development.
- Terminated
- Registry status
- Phase 1
- Development phase
- 25
- Enrollment target
NCT04332523: Clinical Trial Phase 1 study, sponsored by Janssen Research & Development.
NCT04332523 is a Phase 1 study that was terminated before completion, run by Janssen Research & Development. The registered enrollment target is 25 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (58% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04332523, a Phase 1 study, was terminated before completion, sponsored by Janssen Research & Development.
- TERMINATED
- Registry status
- Phase 1
- Development phase
- 25 participants
- Enrollment target
Study Summary
The main purpose of the study is to evaluate the pharmacokinetc (PK) of a single oral dose of JNJ-53718678 in participants with varying degrees of impaired hepatic function (mild, moderate, and severe) when compared with participants with normal hepatic function.
Primary Outcome
Cmax is defined as the maximum plasma concentration of JNJ-53718678.
Interventions
- DRUG JNJ-53718678
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 25 participants |
| Start Date | 2020-08-17 |
| Est. Completion | 2022-03-16 |
| Phase | Phase 1 |
Why NCT04332523 stopped before completion
NCT04332523 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 25 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (58% lower).
The record links to 0 conditions, and to 1 intervention - of which JNJ-53718678 is the first listed.
NCT04332523 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04332523 about?
NCT04332523 is a clinical study titled "A Study of JNJ-53718678 in Participants With Hepatic Impairment". The main purpose of the study is to evaluate the pharmacokinetc (PK) of a single oral dose of JNJ-53718678 in participants with varying degrees of impaired hepatic function (mild, moderate, and severe) when compared with participants with normal hepatic function.
What is the current status of trial NCT04332523?
This trial is currently terminated. It is a Phase 1 study. The enrollment target is 25 participants. The study started on 2020-08-17. Estimated completion is 2022-03-16.
What interventions are being tested in trial NCT04332523?
The interventions under investigation include: JNJ-53718678 (DRUG).
Who is sponsoring clinical trial NCT04332523?
This trial is sponsored by Janssen Research & Development, which has 593 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT04332523's enrollment target sits among peer trials
25 1495th of 2000 higher than 481 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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