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NCT04325503 · ClinicalTrials.gov registry record · Phase 1
Neurobiological Drivers of Mobility Resilience: The Dopaminergic System
A Phase 1 study, sponsored by University of Michigan.
- Completed
- Registry status
- Phase 1
- Development phase
- 14
- Enrollment target
NCT04325503 is a Phase 1 study that has completed, run by University of Michigan. The registered enrollment target is 14 participants.
The verdict
NCT04325503, a Phase 1 study, has completed, sponsored by University of Michigan.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 14 participants
- Enrollment target
Study Summary
Walking with age becomes both slower and less 'automated', requiring more attention and brain resources. As a result, older adults have a greater risk of negative outcomes and falls. There is an urgent need to identify factors that can help compensate for these harmful factors and reduce walking impairments, as there are currently no effective treatments available. Investigators have recently discovered that \~20% of older adults maintain fast walking speed even in the presence of small blood vessel brain changes and leg problems, thus appearing to be protected against these harmful factors. The investigators work suggests that the brain dopamine (DA) system may be a source of this protective capacity. Investigators have also shown that lower levels of dopamine are associated with slow walking. Investigators will be investigating the role of dopamine on slow walking and other parkinsonian signs using detailed clinical assessment, assessment of dopamine activity, and clinical interventions.
Interventions
- DRUG carbidopa
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 14 participants |
| Start Date | 2021-02-08 |
| Est. Completion | 2022-06-30 |
| Phase | Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04325503
The ClinicalTrials.gov registry entry for NCT04325503 describes a study currently listed as completed, categorized as Phase 1. The registered enrollment target is 14 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University of Michigan, which has 1,327 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 1 intervention - of which carbidopa is the first listed.
NCT04325503 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT04325503 about?
NCT04325503 is a clinical study titled "Neurobiological Drivers of Mobility Resilience: The Dopaminergic System". Walking with age becomes both slower and less 'automated', requiring more attention and brain resources. As a result, older adults have a greater risk of negative outcomes and falls. There is an urgent need to identify factors that can help compensate for these harmful factors and reduce walking imp...
What is the current status of trial NCT04325503?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 14 participants. The study started on 2021-02-08. Estimated completion is 2022-06-30.
What interventions are being tested in trial NCT04325503?
The interventions under investigation include: carbidopa (DRUG).
Who is sponsoring clinical trial NCT04325503?
This trial is sponsored by University of Michigan, which has 1,327 total clinical trials registered on ClinicalTrials.gov.
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