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NCT04325503 · ClinicalTrials.gov registry record · Phase 1
Neurobiological Drivers of Mobility Resilience: The Dopaminergic System
A Phase 1 study, sponsored by University of Michigan.
- Completed
- Registry status
- Phase 1
- Development phase
- 14
- Enrollment target
NCT04325503: Completed Phase 1 study, sponsored by University of Michigan.
NCT04325503 is a Phase 1 study that has completed, run by University of Michigan. The registered enrollment target is 14 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (77% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04325503, a Phase 1 study, has completed, sponsored by University of Michigan.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 14 participants
- Enrollment target
Study Summary
Walking with age becomes both slower and less 'automated', requiring more attention and brain resources. As a result, older adults have a greater risk of negative outcomes and falls. There is an urgent need to identify factors that can help compensate for these harmful factors and reduce walking impairments, as there are currently no effective treatments available. Investigators have recently discovered that \~20% of older adults maintain fast walking speed even in the presence of small blood vessel brain changes and leg problems, thus appearing to be protected against these harmful factors. The investigators work suggests that the brain dopamine (DA) system may be a source of this protective capacity. Investigators have also shown that lower levels of dopamine are associated with slow walking. Investigators will be investigating the role of dopamine on slow walking and other parkinsonian signs using detailed clinical assessment, assessment of dopamine activity, and clinical interventions.
Primary Outcome
Average gait speed as measured using wearable sensors worn during walking tasks. Gait speed is measured in meters per second.
Interventions
- DRUG carbidopa
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 14 participants |
| Start Date | 2021-02-08 |
| Est. Completion | 2022-06-30 |
| Phase | Phase 1 |
What the finished NCT04325503 record still lists
NCT04325503 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 14 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (77% lower).
The record links to 0 conditions, and to 1 intervention - of which carbidopa is the first listed.
NCT04325503 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04325503 about?
NCT04325503 is a clinical study titled "Neurobiological Drivers of Mobility Resilience: The Dopaminergic System". Walking with age becomes both slower and less 'automated', requiring more attention and brain resources. As a result, older adults have a greater risk of negative outcomes and falls. There is an urgent need to identify factors that can help compensate for these harmful factors and reduce walking imp...
What is the current status of trial NCT04325503?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 14 participants. The study started on 2021-02-08. Estimated completion is 2022-06-30.
What interventions are being tested in trial NCT04325503?
The interventions under investigation include: carbidopa (DRUG).
Who is sponsoring clinical trial NCT04325503?
This trial is sponsored by University of Michigan, which has 1,327 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT04325503's enrollment target sits among peer trials
14 1844th of 2000 higher than 154 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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