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NCT04284436 · ClinicalTrials.gov registry record · NA
Study in Parkinson Disease of Exercise
A NA study of Parkinson Disease, sponsored by Northwestern University.
- Recruiting
- Registry status
- NA
- Development phase
- 370
- Enrollment target
- 20
- Study locations
NCT04284436: Recruiting NA study of Parkinson Disease, sponsored by Northwestern University.
NCT04284436 is a NA study of Parkinson Disease that is actively recruiting participants, run by Northwestern University. The registered enrollment target is 370 participants, below the 5,325-participant average among 297 other Parkinson Disease trials with a reported enrollment target (93% lower). The trial reports 20 study locations across 15 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04284436, a NA study of Parkinson Disease, is actively recruiting participants, sponsored by Northwestern University.
- RECRUITING
- Registry status
- NA
- Development phase
- 370 participants
- Enrollment target
- 20
- Study locations
Study Summary
This study is a Phase 3 multi-site, randomized, evaluator-masked, study of endurance treadmill exercise on changes in the Movement Disorder Society-Unified Parkinson Disease Rating Scale (MDS-UPDRS) Part III score at 12 months among persons with early stage Parkinson disease. 370 participants will be randomly assigned to 2 groups: 1)60-65% HRmax or 2)80-85% HRmax 4 times per week. The primary objective is to test whether the progression of the signs of Parkinson's disease is attenuated at 12 months in among persons who have not initiated medication for Parkinson Disease (PD) when they perform high-intensity endurance treadmill exercise.
Primary Outcome
Change from baseline in the Movement Disorders Society-Unified Parkinson Disease Rating Scale motor score (Part III). The minimum score on the MDS-UPDRS Part III is 0 and the maximum is 132 with higher scores representing worse motor symptoms.
Conditions Studied
Interventions
- BEHAVIORAL Treadmill walking
Study Locations (20)
Ohio
- University of Cincinnati - Cincinnati
- Cleveland Clinic - Cleveland
- Ohio Health - Columbus
- Kent State University - Kent
Georgia
- Morehouse School of Medicine - Atlanta
- Emory University - Atlanta
Illinois
- Northwestern University - Chicago
- Rush University Medical Center - Chicago
Alabama
- University of Alabama at Birmingham - Birmingham
California
- University of California, San Francisco - San Francisco
Colorado
- University of Colorado, Denver - Aurora
Florida
- University of Florida - Gainesville
Iowa
- Iowa State University - Ames
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 370 participants |
| Start Date | 2021-08-30 |
| Est. Completion | 2028-07-31 |
| Phase | NA |
What NCT04284436 shows while recruiting
NCT04284436 is an interventional study that assigns participants to a tested intervention. The registered 370 participants enrollment target is mid-sized for trials with a published cap, below the 5,325-participant average among 297 other Parkinson Disease trials with a reported enrollment target (93% lower).
The record links to 1 condition, with Parkinson Disease appearing as the primary indexed condition, and to 1 intervention - of which Treadmill walking is the first listed.
NCT04284436 names 20 study sites across 15 states, led by Ohio, Georgia, Illinois.
Frequently Asked Questions
What is clinical trial NCT04284436 about?
NCT04284436 is a clinical study titled "Study in Parkinson Disease of Exercise". This study is a Phase 3 multi-site, randomized, evaluator-masked, study of endurance treadmill exercise on changes in the Movement Disorder Society-Unified Parkinson Disease Rating Scale (MDS-UPDRS) Part III score at 12 months among persons with early stage Parkinson disease. 370 participants will b...
What is the current status of trial NCT04284436?
This trial is currently recruiting. It is a NA study. The enrollment target is 370 participants. The study started on 2021-08-30. Estimated completion is 2028-07-31.
What conditions does trial NCT04284436 study?
This clinical trial studies the following conditions: Parkinson Disease.
What interventions are being tested in trial NCT04284436?
The interventions under investigation include: Treadmill walking (BEHAVIORAL).
Who is sponsoring clinical trial NCT04284436?
This trial is sponsored by Northwestern University, which has 1,209 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04284436 being conducted?
This trial has 20 study locations across Alabama, California, Colorado, Florida, Georgia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04284436's enrollment target sits among peer trials
370 29th of 297 higher than 269 of 297 other Parkinson Disease trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Parkinson Disease trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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