Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT04274530 · ClinicalTrials.gov registry record · NA
Cognitive Behavioural Therapy to Optimize Post-Operative Recovery Trial
A NA study, sponsored by McMaster University.
- Completed
- Registry status
- NA
- Development phase
- 1,024
- Enrollment target
NCT04274530: Completed NA study, sponsored by McMaster University.
NCT04274530 is a NA study that has completed, run by McMaster University. The registered enrollment target is 1,024 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (27% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04274530, a NA study, has completed, sponsored by McMaster University.
- COMPLETED
- Registry status
- NA
- Development phase
- 1,024 participants
- Enrollment target
Study Summary
Psychological factors such as stress, distress, anxiety, depression, and poor coping strategies may be associated with ongoing pain following injuries such as fractures. To study this relationship, patients will undergo cognitive behavioural therapy (CBT) which is designed to modify such thoughts with the goal of reducing ongoing pain and improving quality of life. The goal of this study is to determine if CBT, versus usual care, reduces the prevalence of moderate to severe persistent post-surgical pain (PPSP) over 12-months post-fracture in patients with an open or closed fracture of the appendicular skeleton, treated with internal fixation.
Primary Outcome
The primary outcome is PPSP according to the World Health Organization's (WHO) proposed definition. The WHO's definition requires 4 criteria for the diagnosis of PPSP: 1) Pain that began after surgery or a tissue trauma is experienced; 2) The pain is in an area of preceding surgery or tissue trauma, 3) The pain persisted for at least three months after the initiating event, and 4) The pain is not better explained by an infection, a malignancy, a pre-existing pain condition or any other alternat
Interventions
- BEHAVIORAL Cognitive Behavioural Therapy
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 1,024 participants |
| Start Date | 2021-01-25 |
| Est. Completion | 2025-08-18 |
| Phase | NA |
What the finished NCT04274530 record still lists
NCT04274530 is an interventional study that assigns participants to a tested intervention. Its 1,024 participants enrollment target places it among the larger protocols in the corpus, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (27% lower).
The record links to 0 conditions, and to 1 intervention - of which Cognitive Behavioural Therapy is the first listed.
NCT04274530 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04274530 about?
NCT04274530 is a clinical study titled "Cognitive Behavioural Therapy to Optimize Post-Operative Recovery Trial". Psychological factors such as stress, distress, anxiety, depression, and poor coping strategies may be associated with ongoing pain following injuries such as fractures. To study this relationship, patients will undergo cognitive behavioural therapy (CBT) which is designed to modify such thoughts wi...
What is the current status of trial NCT04274530?
This trial is currently completed. It is a NA study. The enrollment target is 1,024 participants. The study started on 2021-01-25. Estimated completion is 2025-08-18.
What interventions are being tested in trial NCT04274530?
The interventions under investigation include: Cognitive Behavioural Therapy (BEHAVIORAL).
Who is sponsoring clinical trial NCT04274530?
This trial is sponsored by McMaster University, which has 31 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT04274530's enrollment target sits among peer trials
1,024 105th of 2000 higher than 1,895 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT06888011 · 1,024 participants · NA
iAmHealthy Clinical Practice Guideline (CPG)
- NCT02200276 · 1,025 participants · NA
Influenza Immunization in Adults Over Age 75
- NCT02296450 · 1,025 participants
Quality of Life (QoL) Assessment in Cancer Patients and Survivors With Dermatologic Conditions Using Dermatologic QoL Instruments
- NCT07216703 · 1,023 participants · Phase 3
A Clinical Study of Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab (MK-3475) as First-line Maintenance Treatment of Cervical Cancer (MK-2870-036/TroFuse-036/GOG-3123/ENGOT-cx22)
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI