Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

RECRUITING Phase 3

A Clinical Study of Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab (MK-3475) as First-line Maintenance Treatment of Cervical Cancer (MK-2870-036/TroFuse-036/GOG-3123/ENGOT-cx22)

NCT07216703 · View on ClinicalTrials.gov ↗

Study Summary

Researchers are looking for new ways to treat metastatic cervical cancer. Cervical cancer is cancer in the cervix, the lower part of the uterus (womb). Metastatic means the cancer has spread to other parts of the body. Researchers want to learn about giving the study medicine sacituzumab tirumotecan (also called sac-TMT or MK-2870) along with pembrolizumab and bevacizumab treatments. Sac-TMT is an antibody drug conjugate, which is a type of medicine that attaches to specific targets on cancer cells and delivers treatment to destroy those cells. The goals of this study are to learn: * About the safety of sac-TMT with pembrolizumab and bevacizumab, and if people tolerate them when given together, and * If people who receive sac-TMT and pembrolizumab, with or without bevacizumab, live longer overall or without their cancer getting worse as compared to those who receive standard treatment

Conditions Studied

Interventions

  • BIOLOGICAL Pembrolizumab
  • DRUG Cisplatin
  • DRUG Paclitaxel
  • BIOLOGICAL Bevacizumab
  • BIOLOGICAL Sacituzumab Tirumotecan

Study Locations (20)

Quebec

  • Centre Hospitalier de l'Université de Montréal ( Site 0616) — Montreal
  • McGill University Health Centre ( Site 0602) — Montreal
  • Centre intégré de cancérologie du CHU de Québec Université Laval, Hôpital de l'Enfant-Jésus ( Site 0611) — Québec

Santa Fe Province

  • Instituto de Oncologia de Rosario ( Site 0104) — Rosario
  • Hospital Provincial del Centenario ( Site 0106) — Rosario

Moravskoslezský kraj

  • Nemocnice AGEL Novy Jicin a.s. ( Site 1004) — Nový Jičín
  • Fakultni nemocnice Ostrava ( Site 1005) — Ostrava

Florida

  • Mount Sinai Comprehensive Cancer Center ( Site 6000) — Miami Beach

Louisiana

  • TRIALS 365 ( Site 6008) — Shreveport

Nevada

  • Women's Cancer Center of Nevada ( Site 6011) — Las Vegas

New York

  • Laura and Isaac Perlmutter Cancer Center at NYU Langone ( Site 6009) — New York

Tennessee

  • University of Tennessee Medical Center ( Site 6012) — Knoxville

Trial Details

FieldValue
Enrollment Target 1,023 participants
Start Date 2026-01-19
Est. Completion 2031-10-29
Phase Phase 3

Sponsor

Merck Sharp & Dohme

741 total trials

Interested in This Trial?

Always speak with your doctor before enrolling in a clinical trial.

Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT07216703

The ClinicalTrials.gov registry entry for NCT07216703 describes a study currently listed as recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 1,023 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Merck Sharp & Dohme, which has 741 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Cervical Cancer appearing as the primary indexed condition, and to 5 interventions — of which Pembrolizumab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT07216703 reports 20 study locations spanning 16 distinct geographic areas — top geographies include Quebec, Santa Fe Province, Moravskoslezský kraj. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT07216703 about?

NCT07216703 is a clinical study titled "A Clinical Study of Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab (MK-3475) as First-line Maintenance Treatment of Cervical Cancer (MK-2870-036/TroFuse-036/GOG-3123/ENGOT-cx22)". Researchers are looking for new ways to treat metastatic cervical cancer. Cervical cancer is cancer in the cervix, the lower part of the uterus (womb). Metastatic means the cancer has spread to other parts of the body. Researchers want to learn about giving the study medicine sacituzumab tirumoteca...

What is the current status of trial NCT07216703?

This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 1,023 participants. The study started on 2026-01-19. Estimated completion is 2031-10-29.

What conditions does trial NCT07216703 study?

This clinical trial studies the following conditions: Cervical Cancer. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT07216703?

The interventions under investigation include: Pembrolizumab (BIOLOGICAL), Cisplatin (DRUG), Paclitaxel (DRUG), Bevacizumab (BIOLOGICAL), Sacituzumab Tirumotecan (BIOLOGICAL). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT07216703?

This trial is sponsored by Merck Sharp & Dohme, which has 741 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT07216703 being conducted?

This trial has 20 study locations across Florida, Louisiana, Nevada, New York, Tennessee. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial