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NCT04273022 · ClinicalTrials.gov registry record · NA
Effect of Exercise on Biomarkers in SCT
A NA study, sponsored by St. Louis University.
- Completed
- Registry status
- NA
- Development phase
- 12
- Enrollment target
NCT04273022: Completed NA study, sponsored by St. Louis University.
NCT04273022 is a NA study that has completed, run by St. Louis University. The registered enrollment target is 12 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04273022, a NA study, has completed, sponsored by St. Louis University.
- COMPLETED
- Registry status
- NA
- Development phase
- 12 participants
- Enrollment target
Study Summary
This study measures the effect of exercise on a variety of biomarkers in blood and urine selected to evaluate the physiological pathways of hemolysis, myolysis, thrombosis, inflammation, and renal function in subjects with sickle cell trait. These pathways have been shown to be associated with adverse events in athletes and warfighters with SCT upon protracted, repeated, strenuous exertion. Changes in biomarkers post-exercise compared to pre-exercise (and compared to healthy controls) suggest activation of the associated pathway(s) which may contribute to exercise-related events in athletes and warfighters and subclinical complications in non-athletes.
Primary Outcome
Reticulocytes will be counting using a manual microscopic method (New Methylene Blue) from blood collected in EDTA and reported as percentage of reticulocytes per 100 erythrocytes. Elevated reticulocytes suggest the bone marrow response to hemolysis.
Interventions
- OTHER Exercise
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 12 participants |
| Start Date | 2021-12-27 |
| Est. Completion | 2024-12-31 |
| Phase | NA |
What the finished NCT04273022 record still lists
NCT04273022 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 12 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower).
The record links to 0 conditions, and to 1 intervention - of which Exercise is the first listed.
NCT04273022 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04273022 about?
NCT04273022 is a clinical study titled "Effect of Exercise on Biomarkers in SCT". This study measures the effect of exercise on a variety of biomarkers in blood and urine selected to evaluate the physiological pathways of hemolysis, myolysis, thrombosis, inflammation, and renal function in subjects with sickle cell trait. These pathways have been shown to be associated with adver...
What is the current status of trial NCT04273022?
This trial is currently completed. It is a NA study. The enrollment target is 12 participants. The study started on 2021-12-27. Estimated completion is 2024-12-31.
What interventions are being tested in trial NCT04273022?
The interventions under investigation include: Exercise (OTHER).
Who is sponsoring clinical trial NCT04273022?
This trial is sponsored by St. Louis University, which has 107 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT04273022's enrollment target sits among peer trials
12 1913th of 2000 higher than 74 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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