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RECRUITING NA

A Study to Compare Two Surgical Procedures in Individuals With BRCA1 Mutations to Assess Reduced Risk of Ovarian Cancer

NCT04251052 · View on ClinicalTrials.gov ↗

Study Summary

This clinical trial evaluates how well two surgical procedures (bilateral salpingectomy and bilateral salpingo-oophorectomy) work in reducing the risk of ovarian cancer for individuals with BRCA1 mutations. Bilateral salpingectomy involves the surgical removal of fallopian tubes, and bilateral salpingo-oophorectomy involves the surgical removal of both the fallopian tubes and ovaries. This study may help doctors determine if the two surgical procedures are nearly the same for ovarian cancer risk reduction for women with BRCA1 mutations.

Conditions Studied

Interventions

  • PROCEDURE Biospecimen Collection
  • OTHER Quality-of-Life Assessment
  • PROCEDURE Magnetic Resonance Imaging
  • PROCEDURE Bilateral Salpingectomy
  • PROCEDURE Bilateral Salpingectomy with Oophorectomy

Study Locations (20)

California

  • Kaiser Permanente-Deer Valley Medical Center — Antioch
  • Tower Cancer Research Foundation — Beverly Hills
  • Keck Medicine of USC Buena Park — Buena Park
  • Providence Saint Joseph Medical Center/Disney Family Cancer Center — Burbank
  • Mercy Cancer Center - Carmichael — Carmichael
  • Mercy San Juan Medical Center — Carmichael
  • City of Hope Comprehensive Cancer Center — Duarte
  • Kaiser Permanente Dublin — Dublin

Alaska

  • Anchorage Associates in Radiation Medicine — Anchorage
  • Anchorage Radiation Therapy Center — Anchorage
  • Alaska Breast Care and Surgery LLC — Anchorage
  • Alaska Oncology and Hematology LLC — Anchorage
  • Alaska Women's Cancer Care — Anchorage
  • Katmai Oncology Group — Anchorage
  • Providence Alaska Medical Center — Anchorage

Arizona

  • CTCA at Western Regional Medical Center — Goodyear
  • Banner University Medical Center - Tucson — Tucson
  • University of Arizona Cancer Center-North Campus — Tucson

Alabama

  • University of Alabama at Birmingham Cancer Center — Birmingham

Arkansas

  • University of Arkansas for Medical Sciences — Little Rock

Trial Details

FieldValue
Enrollment Target 1,956 participants
Start Date 2020-09-01
Est. Completion 2047-06-30
Phase NA

Sponsor

NRG Oncology

162 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT04251052

The ClinicalTrials.gov registry entry for NCT04251052 describes a study currently listed as recruiting. It is categorized as NA, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 1,956 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is NRG Oncology, which has 162 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Ovarian Carcinoma appearing as the primary indexed condition, and to 5 interventions — of which Biospecimen Collection is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT04251052 reports 20 study locations spanning 5 distinct geographic areas — top geographies include California, Alaska, Arizona. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT04251052 about?

NCT04251052 is a clinical study titled "A Study to Compare Two Surgical Procedures in Individuals With BRCA1 Mutations to Assess Reduced Risk of Ovarian Cancer". This clinical trial evaluates how well two surgical procedures (bilateral salpingectomy and bilateral salpingo-oophorectomy) work in reducing the risk of ovarian cancer for individuals with BRCA1 mutations. Bilateral salpingectomy involves the surgical removal of fallopian tubes, and bilateral salpi...

What is the current status of trial NCT04251052?

This trial is currently recruiting. It is a NA study. The enrollment target is 1,956 participants. The study started on 2020-09-01. Estimated completion is 2047-06-30.

What conditions does trial NCT04251052 study?

This clinical trial studies the following conditions: Ovarian Carcinoma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT04251052?

The interventions under investigation include: Biospecimen Collection (PROCEDURE), Quality-of-Life Assessment (OTHER), Magnetic Resonance Imaging (PROCEDURE), Bilateral Salpingectomy (PROCEDURE), Bilateral Salpingectomy with Oophorectomy (PROCEDURE). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT04251052?

This trial is sponsored by NRG Oncology, which has 162 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT04251052 being conducted?

This trial has 20 study locations across Alabama, Alaska, Arizona, Arkansas, California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial