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NCT04236388 · ClinicalTrials.gov registry record · NA
Short Term Ketone Supplementation and Cardiometabolic Health
A NA study, sponsored by Virginia Polytechnic Institute and State University.
- Completed
- Registry status
- NA
- Development phase
- 11
- Enrollment target
NCT04236388: Completed NA study, sponsored by Virginia Polytechnic Institute and State University.
NCT04236388 is a NA study that has completed, run by Virginia Polytechnic Institute and State University. The registered enrollment target is 11 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04236388, a NA study, has completed, sponsored by Virginia Polytechnic Institute and State University.
- COMPLETED
- Registry status
- NA
- Development phase
- 11 participants
- Enrollment target
Study Summary
The purpose of this research study is to determine if short-term consumption of a dietary ketone drink, which increases the blood circulation concentrations of beta-hydroxybutyrate, a ketone, affects blood vessel health and cognitive health in adults. Ketones are normally produced by the liver when people fast longer than 16-24 hours or eat a diet low in carbohydrates. Participants will be asked to randomly consume a dietary ketone drink and placebo (flavored water) for a 2-week period each in a crossover fashion with a 2-week washout period while maintaining habitual diet and physical activity patterns. The investigators hypothesize that consumption of a ketone drink will reduce BP and improve vascular health by reducing aortic pulse wave velocity and increasing brachial artery flow mediated dilation. Furthermore, they hypothesize that ketone consumption will improve cognitive health by increasing attention and processing speed.
Primary Outcome
The blood flow and diameter in the common arteries in the neck will be measured from the image obtained from an ultrasound unit (GE Vivid S6) equipped with a high-resolution linear array transducer. For applanation tonometry, the carotid, brachial, radial and femoral artery pressure waveform and amplitude will be obtained by a fingertip probe incorporating a high-fidelity strain gauge transducer. Each of these measures are used to calculate arterial stiffness. These tests will be conducted two t
Interventions
- DIETARY_SUPPLEMENT Placebo drink
- DIETARY_SUPPLEMENT Ketone drink
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 11 participants |
| Start Date | 2020-10-02 |
| Est. Completion | 2022-05-25 |
| Phase | NA |
What the finished NCT04236388 record still lists
NCT04236388 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 11 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower).
The record links to 0 conditions, and to 2 interventions - of which Placebo drink is the first listed.
NCT04236388 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04236388 about?
NCT04236388 is a clinical study titled "Short Term Ketone Supplementation and Cardiometabolic Health". The purpose of this research study is to determine if short-term consumption of a dietary ketone drink, which increases the blood circulation concentrations of beta-hydroxybutyrate, a ketone, affects blood vessel health and cognitive health in adults. Ketones are normally produced by the liver when ...
What is the current status of trial NCT04236388?
This trial is currently completed. It is a NA study. The enrollment target is 11 participants. The study started on 2020-10-02. Estimated completion is 2022-05-25.
What interventions are being tested in trial NCT04236388?
The interventions under investigation include: Placebo drink (DIETARY_SUPPLEMENT), Ketone drink (DIETARY_SUPPLEMENT).
Who is sponsoring clinical trial NCT04236388?
This trial is sponsored by Virginia Polytechnic Institute and State University, which has 104 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT04236388's enrollment target sits among peer trials
11 1927th of 2000 higher than 74 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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