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NCT04226469 · ClinicalTrials.gov registry record
Gingival Crevicular Fluid Characterization During Orthodontic Treatment
A clinical trial, sponsored by University of Illinois at Chicago.
- Completed
- Registry status
- 15
- Enrollment target
NCT04226469: Completed study, sponsored by University of Illinois at Chicago.
NCT04226469 is a clinical trial that has completed, run by University of Illinois at Chicago. The registered enrollment target is 15 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04226469 has completed, sponsored by University of Illinois at Chicago.
- COMPLETED
- Registry status
- 15 participants
- Enrollment target
Study Summary
During Orthodontic tooth movement, teeth are moved through alveolar bone under applied forces. The applied mechanical loading force must be transferred to the alveolar bone via periodontal ligament (PDL). This process of mechanotransduction stimulates bone remodeling during which osteoblasts produce bone on the tension side and osteoclasts resorb bone on the compression side of the PDL. Complex interactions between osteoblasts and osteoclasts involve numerous biologic molecules including cytokines and growth factors. During the tooth movement, the expression of cytokines such as interleukin (IL)-1β, IL-6, IL-8, prostaglandin E2, RANKL and MMP1 in PDL will be up-regulated. The sequence of events from the mechanotransduction commanding the tightly controlled accomplishment of osteogenesis attention sides and osteoclastogenesis at compressive sides is not completely understood. The gingival crevicular fluid (GCF) is a transudate of interstitial tissues that is produced by an osmotic gradient and it is released into the crevicular crevices at a flow rate of about 3 ul/h. Orthodontic treatment is triggered by an inflammatory process and it has been hypothesized that the quantification of specific biomarkers within the GCF can be determined using Periotron. However contrasting results have been reported in the literature, which studies showing both increased or unchanged GCF volumes incident to orthodontic treatment. Given that the orthodontic treatment is triggered by a set of inflammatory cytokines that are released into the crevicular fluid during the mechanical loading, and its homeostasis is dependent on mechanical stimulation. An understanding of the biological response of crevicular fluid to mechanical loading could further advance the knowledge of orthodontic treatment. In this study, the investigators will investigate the biological response of gingival crevicular fluid before and after the initial wire placement of orthodontic treatment to determine the diffe
Primary Outcome
The distance of tooth movement from initial timepoint to the end of study
Interventions
- PROCEDURE Tooth movement
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 15 participants |
| Start Date | 2019-01-01 |
| Est. Completion | 2021-05-05 |
What the finished NCT04226469 record still lists
NCT04226469 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 15 participants, a relatively small participant target.
The record links to 0 conditions, and to 1 intervention - of which Tooth movement is the first listed.
NCT04226469 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04226469 about?
NCT04226469 is a clinical study titled "Gingival Crevicular Fluid Characterization During Orthodontic Treatment". During Orthodontic tooth movement, teeth are moved through alveolar bone under applied forces. The applied mechanical loading force must be transferred to the alveolar bone via periodontal ligament (PDL). This process of mechanotransduction stimulates bone remodeling during which osteoblasts produce...
What is the current status of trial NCT04226469?
This trial is currently completed. The enrollment target is 15 participants. The study started on 2019-01-01. Estimated completion is 2021-05-05.
What interventions are being tested in trial NCT04226469?
The interventions under investigation include: Tooth movement (PROCEDURE).
Who is sponsoring clinical trial NCT04226469?
This trial is sponsored by University of Illinois at Chicago, which has 430 total clinical trials registered on ClinicalTrials.gov.
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