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NCT04214886 · ClinicalTrials.gov registry record · Phase 1
CD19 Chimeric Antigen Receptor (CAR) T Cells for Adults With Recurrent or Refractory B Cell Malignancies
A Phase 1 study of B-Cell Acute Lymphoblastic Leukemia, Adult and B-cell Lymphoma Refractory, sponsored by Loyola University.
- Active
- Registry status
- Phase 1
- Development phase
- 24
- Enrollment target
- 1
- Study location
NCT04214886 is a Phase 1 study of B-Cell Acute Lymphoblastic Leukemia, Adult and B-cell Lymphoma Refractory that is active but no longer recruiting, run by Loyola University. The registered enrollment target is 24 participants. The trial reports 1 study location across 1 state.
The verdict
NCT04214886, a Phase 1 study of B-Cell Acute Lymphoblastic Leukemia, Adult and B-cell Lymphoma Refractory, is active but no longer recruiting, sponsored by Loyola University.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 1
- Development phase
- 24 participants
- Enrollment target
- 1
- Study location
Study Summary
In this protocol, the investigators hypothesize that modifying the process of producing CAR+ T-cells can help to improve responses and reduce toxicities. Building on previous in vitro studies that have shown successful production of CAR+ T-cells using a new production approach, the investigators are now studying the ability to produce these CAR+ T-cells and determine how well they work in the clinical setting.
Conditions Studied
Interventions
- DRUG Cyclophosphamide
- DRUG Fludarabine
- BIOLOGICAL CD19-CD34 CAR transduced T cells
Study Locations (1)
Illinois
- Loyola University - Maywood
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 24 participants |
| Start Date | 2019-12-31 |
| Est. Completion | 2034-12-31 |
| Phase | Phase 1 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04214886
The ClinicalTrials.gov registry entry for NCT04214886 describes a study currently listed as active not recruiting, categorized as Phase 1. The registered enrollment target is 24 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Loyola University, which has 92 total studies on file at ClinicalTrials.gov.
The record links to 3 conditions, with B-Cell Acute Lymphoblastic Leukemia, Adult appearing as the primary indexed condition, and to 3 interventions - of which Cyclophosphamide is the first listed.
NCT04214886 reports 1 study location spanning 1 distinct geographic area - top geographies include Illinois.
Frequently Asked Questions
What is clinical trial NCT04214886 about?
NCT04214886 is a clinical study titled "CD19 Chimeric Antigen Receptor (CAR) T Cells for Adults With Recurrent or Refractory B Cell Malignancies". In this protocol, the investigators hypothesize that modifying the process of producing CAR+ T-cells can help to improve responses and reduce toxicities. Building on previous in vitro studies that have shown successful production of CAR+ T-cells using a new production approach, the investigators are...
What is the current status of trial NCT04214886?
This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 24 participants. The study started on 2019-12-31. Estimated completion is 2034-12-31.
What conditions does trial NCT04214886 study?
This clinical trial studies the following conditions: B-Cell Acute Lymphoblastic Leukemia, Adult, B-cell Lymphoma Refractory, B-cell Lymphoma Recurrent.
What interventions are being tested in trial NCT04214886?
The interventions under investigation include: Cyclophosphamide (DRUG), Fludarabine (DRUG), CD19-CD34 CAR transduced T cells (BIOLOGICAL).
Who is sponsoring clinical trial NCT04214886?
This trial is sponsored by Loyola University, which has 92 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04214886 being conducted?
This trial has 1 study location across Illinois. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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