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NCT04198818 · ClinicalTrials.gov registry record · Phase 1
A Study to Evaluate the Safety, Tolerability and Pharmacokinetics of HH2710 in Patient With Advanced Tumors
A Phase 1 study, sponsored by Haihe Biopharma Co..
- Terminated
- Registry status
- Phase 1
- Development phase
- 37
- Enrollment target
NCT04198818: Clinical Trial Phase 1 study, sponsored by Haihe Biopharma Co..
NCT04198818 is a Phase 1 study that was terminated before completion, run by Haihe Biopharma Co.. The registered enrollment target is 37 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (38% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04198818, a Phase 1 study, was terminated before completion, sponsored by Haihe Biopharma Co..
- TERMINATED
- Registry status
- Phase 1
- Development phase
- 37 participants
- Enrollment target
Study Summary
This is a First-in-Human, Open Label, Phase I/II Study to Evaluate the Safety, Tolerability and Pharmacokinetics of HH2710 in Patients with Advanced Tumors, composed of a Phase I dose escalation and dose expansion stage and a Phase II dose extension stage.
Primary Outcome
MTD estimation: After the escalation is completed, select the MTD based on the isotonic regression. Specifically, select the MTD for which the isotonic estimate of the toxicity rate is closest to the target toxicity rate. If there are ties, select the higher dose level when the isotonic estimate is lower than the target toxicity rate and select the lower dose level when the isotonic estimate is greater than or equal to the target toxicity rate.
Interventions
- DRUG HH2710
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 37 participants |
| Start Date | 2020-01-07 |
| Est. Completion | 2023-03-31 |
| Phase | Phase 1 |
Why NCT04198818 stopped before completion
NCT04198818 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 37 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (38% lower).
The record links to 0 conditions, and to 1 intervention - of which HH2710 is the first listed.
NCT04198818 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04198818 about?
NCT04198818 is a clinical study titled "A Study to Evaluate the Safety, Tolerability and Pharmacokinetics of HH2710 in Patient With Advanced Tumors". This is a First-in-Human, Open Label, Phase I/II Study to Evaluate the Safety, Tolerability and Pharmacokinetics of HH2710 in Patients with Advanced Tumors, composed of a Phase I dose escalation and dose expansion stage and a Phase II dose extension stage.
What is the current status of trial NCT04198818?
This trial is currently terminated. It is a Phase 1 study. The enrollment target is 37 participants. The study started on 2020-01-07. Estimated completion is 2023-03-31.
What interventions are being tested in trial NCT04198818?
The interventions under investigation include: HH2710 (DRUG).
Who is sponsoring clinical trial NCT04198818?
This trial is sponsored by Haihe Biopharma Co., which has 4 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT04198818's enrollment target sits among peer trials
37 1204th of 2000 higher than 791 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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