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NCT04196374 · ClinicalTrials.gov registry record · NA
Return of Genomic Results and Aggregate Penetrance in Population-Based Cohorts
A NA study, sponsored by Brigham and Women's Hospital.
- Completed
- Registry status
- NA
- Development phase
- 48
- Enrollment target
NCT04196374: Completed NA study, sponsored by Brigham and Women's Hospital.
NCT04196374 is a NA study that has completed, run by Brigham and Women's Hospital. The registered enrollment target is 48 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (97% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04196374, a NA study, has completed, sponsored by Brigham and Women's Hospital.
- COMPLETED
- Registry status
- NA
- Development phase
- 48 participants
- Enrollment target
Study Summary
The PopSeq Project is a prospective cohort study that will develop and implement a genomic return of results (gRoR) process in the Framingham Heart Study (FHS) and Jackson Heart Study (JHS) cohorts and explore associated medical, behavioral, and economic outcomes. The study will interpret the genomic sequences of JHS/FHS participants previously sequenced by TOPMed who have consented to genomic return of results and/or genetic testing. We will develop and apply new methods for scalable screening/ classification of genomic variants and will explore genomic penetrance by phenotyping a subset of participants in the FHS and JHS.
Primary Outcome
Living JHS/FHS participants sequenced as part of the TOPMed program who were notified about an actionable genetic result that warranted having the research result verified who followed through with having their result confirmed and disclosed to their health care provider.
Interventions
- GENETIC Genomic Sequencing
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 48 participants |
| Start Date | 2021-06-09 |
| Est. Completion | 2025-05-30 |
| Phase | NA |
What the finished NCT04196374 record still lists
NCT04196374 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 48 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (97% lower).
The record links to 0 conditions, and to 1 intervention - of which Genomic Sequencing is the first listed.
NCT04196374 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04196374 about?
NCT04196374 is a clinical study titled "Return of Genomic Results and Aggregate Penetrance in Population-Based Cohorts". The PopSeq Project is a prospective cohort study that will develop and implement a genomic return of results (gRoR) process in the Framingham Heart Study (FHS) and Jackson Heart Study (JHS) cohorts and explore associated medical, behavioral, and economic outcomes. The study will interpret the genomi...
What is the current status of trial NCT04196374?
This trial is currently completed. It is a NA study. The enrollment target is 48 participants. The study started on 2021-06-09. Estimated completion is 2025-05-30.
What interventions are being tested in trial NCT04196374?
The interventions under investigation include: Genomic Sequencing (GENETIC).
Who is sponsoring clinical trial NCT04196374?
This trial is sponsored by Brigham and Women's Hospital, which has 937 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT04196374's enrollment target sits among peer trials
48 1381st of 2000 higher than 601 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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