Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT04192773 · ClinicalTrials.gov registry record · Early Phase 1
An fMRI Investigation of the Effects of IV Lidocaine on Tinnitus
A Early Phase 1 study of Tinnitus, sponsored by D. Bradley Welling, MD, PhD.
- Recruiting
- Registry status
- Early Phase 1
- Development phase
- 40
- Enrollment target
- 1
- Study location
NCT04192773: Recruiting Early Phase 1 study of Tinnitus, sponsored by D. Bradley Welling, MD, PhD.
NCT04192773 is a Early Phase 1 study of Tinnitus that is actively recruiting participants, run by D. Bradley Welling, MD, PhD. The registered enrollment target is 40 participants, below the 12,618-participant average among 24 other Tinnitus trials with a reported enrollment target (100% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04192773, a Early Phase 1 study of Tinnitus, is actively recruiting participants, sponsored by D. Bradley Welling, MD, PhD.
- RECRUITING
- Registry status
- Early Phase 1
- Development phase
- 40 participants
- Enrollment target
- 1
- Study location
Study Summary
This is an exploratory pilot open-label study to identify the signal changes on fMRI of patients with tinnitus and with temporary suppression of the tinnitus with IV lidocaine. Patients will include those with hearing loss (both unilateral and bilateral) and tinnitus, subjects with normal hearing and tinnitus, and control subjects with normal hearing and no tinnitus. Eligible subjects will have functional and subjective data collected at baseline, receive an IV lidocaine infusion, and have functional and subjective data collected post-infusion for comparison and identification of involved neural networks.
Primary Outcome
The investigators will scan the patient in fMRI prior to IV lidocaine administration. After the infusion, patient will get another fMRI scan to assess any neural changes in the primary auditory cortex and associated salience, limbic and cognitive regions.
Conditions Studied
Interventions
- DRUG IV Lidocaine
Study Locations (1)
Massachusetts
- Massachusetts Eye and Ear Infirmary - Boston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 40 participants |
| Start Date | 2021-04-28 |
| Est. Completion | 2027-12-31 |
| Phase | Early Phase 1 |
What NCT04192773 shows while recruiting
NCT04192773 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 40 participants, a relatively small participant target, below the 12,618-participant average among 24 other Tinnitus trials with a reported enrollment target (100% lower).
The record links to 1 condition, with Tinnitus appearing as the primary indexed condition, and to 1 intervention - of which IV Lidocaine is the first listed.
NCT04192773 reports a single indexed study location in Massachusetts.
Frequently Asked Questions
What is clinical trial NCT04192773 about?
NCT04192773 is a clinical study titled "An fMRI Investigation of the Effects of IV Lidocaine on Tinnitus". This is an exploratory pilot open-label study to identify the signal changes on fMRI of patients with tinnitus and with temporary suppression of the tinnitus with IV lidocaine. Patients will include those with hearing loss (both unilateral and bilateral) and tinnitus, subjects with normal hearing an...
What is the current status of trial NCT04192773?
This trial is currently recruiting. It is a Early Phase 1 study. The enrollment target is 40 participants. The study started on 2021-04-28. Estimated completion is 2027-12-31.
What conditions does trial NCT04192773 study?
This clinical trial studies the following conditions: Tinnitus.
What interventions are being tested in trial NCT04192773?
The interventions under investigation include: IV Lidocaine (DRUG).
Who is sponsoring clinical trial NCT04192773?
This trial is sponsored by D. Bradley Welling, MD, PhD, which has 3 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04192773 being conducted?
This trial has 1 study location across Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Tinnitus
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04192773's enrollment target sits among peer trials
40 19th of 24 higher than 5 of 24 other Tinnitus trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Tinnitus trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
Treatment for PTSD and Tinnitus
RECRUITING · NA
-
Investigating EEG as a Biomarker for Tinnitus Improvement After Bimodal Stimulation
RECRUITING · NA
-
Somatosensory Tinnitus RCT
RECRUITING · NA
-
Noninvasive Therapy for Tinnitus
RECRUITING · NA
-
External Therapy for Tinnitus Management
RECRUITING · NA
-
Treatment of Tinnitus With Migraine Medications
RECRUITING · Phase 4
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT01306019 · 40 participants · Phase 1
Lentiviral Gene Transfer for Treatment of Children Older Than Two Years of Age With X-Linked Severe Combined Immunodeficiency (XSCID)
- NCT01608152 · 40 participants
Development of a Video Game for the Improvement of Outcomes in Stem Cell Transplant Survivors
- NCT01668082 · 40 participants · NA
An Investigation of Brain Tumor Metabolism in Patients Undergoing Surgical Resection
- NCT02015013 · 40 participants · Phase 2
Hematopoietic Stem Cell Mobilization in Idiopathic CD4 Lymphocytopenia Patients and Healthy Controls for the Study of T Cell Maturation and Trafficking in Murine Models
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI