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NCT04192136 · ClinicalTrials.gov registry record · NA
NAD+ and Exercise in FA
A NA study, sponsored by Children's Hospital of Philadelphia.
- Completed
- Registry status
- NA
- Development phase
- 75
- Enrollment target
NCT04192136: Completed NA study, sponsored by Children's Hospital of Philadelphia.
NCT04192136 is a NA study that has completed, run by Children's Hospital of Philadelphia. The registered enrollment target is 75 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (95% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04192136, a NA study, has completed, sponsored by Children's Hospital of Philadelphia.
- COMPLETED
- Registry status
- NA
- Development phase
- 75 participants
- Enrollment target
Study Summary
Randomized, placebo-controlled trial with a 2x2 factorial design testing the effects of an NAD+ precursor (NR) and exercise on Peak VO2 and Si in Friedreich's Ataxia (FA). The primary objective of this research is to measure the effect of combination administration (NR + exercise) on aerobic capacity (Peak VO2) in FA. A key secondary objective is to measure the effect of combination administration (NR + exercise) on glucose homeostasis (Si) in FA.
Primary Outcome
Peak V02 will be assessed by completion of an incremental symptom-limited cardio-pulmonary Exercise Stress Test (EST) on a recumbent leg cycle ergometer. The index is based on the change in peak V02 given in liters per minute (L/min), and a higher value indicates greater oxygen uptake.
Interventions
- DIETARY_SUPPLEMENT Placebo
- OTHER Exercise Intervention
- DIETARY_SUPPLEMENT Nicotinamide Riboside
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 75 participants |
| Start Date | 2020-09-03 |
| Est. Completion | 2025-10-31 |
| Phase | NA |
What the finished NCT04192136 record still lists
NCT04192136 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 75 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (95% lower).
The record links to 0 conditions, and to 3 interventions - of which Placebo is the first listed.
NCT04192136 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04192136 about?
NCT04192136 is a clinical study titled "NAD+ and Exercise in FA". Randomized, placebo-controlled trial with a 2x2 factorial design testing the effects of an NAD+ precursor (NR) and exercise on Peak VO2 and Si in Friedreich's Ataxia (FA). The primary objective of this research is to measure the effect of combination administration (NR + exercise) on aerobic capaci...
What is the current status of trial NCT04192136?
This trial is currently completed. It is a NA study. The enrollment target is 75 participants. The study started on 2020-09-03. Estimated completion is 2025-10-31.
What interventions are being tested in trial NCT04192136?
The interventions under investigation include: Placebo (DIETARY_SUPPLEMENT), Exercise Intervention (OTHER), Nicotinamide Riboside (DIETARY_SUPPLEMENT).
Who is sponsoring clinical trial NCT04192136?
This trial is sponsored by Children's Hospital of Philadelphia, which has 431 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT04192136's enrollment target sits among peer trials
75 1069th of 2000 higher than 919 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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