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NCT04182906 · ClinicalTrials.gov registry record · NA
Pediatric ACEs Screening and Resiliency Study
A NA study, sponsored by UCSF Benioff Children's Hospital Oakland.
- Completed
- Registry status
- NA
- Development phase
- 555
- Enrollment target
NCT04182906: Completed NA study, sponsored by UCSF Benioff Children's Hospital Oakland.
NCT04182906 is a NA study that has completed, run by UCSF Benioff Children's Hospital Oakland. The registered enrollment target is 555 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (60% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04182906, a NA study, has completed, sponsored by UCSF Benioff Children's Hospital Oakland.
- COMPLETED
- Registry status
- NA
- Development phase
- 555 participants
- Enrollment target
Study Summary
Stressful and traumatic experiences in childhood (Adverse Childhood Events, or ACEs) have been associated with poor health outcomes that extend into adulthood. When stress is sustained or severe in the absence of an adequate buffer, the stress response can become dysregulated--a state referred to as toxic stress. Some professional organizations have advocated for ACEs screening to be part of routine medical care. To date, however, no ACEs screening tool has been validated for use with children. Intervening early at critical points in the life course has the potential to allow a child to avoid the negative consequences of these adverse events. The proposed study has three overarching aims: (1) Examine the relationship between ACEs, stress biomarkers, and symptoms in children and caregivers over time; (2) Validate an ACEs screening in a pediatric health care setting; and (3) Test whether providing primary care-based preventive interventions for children with or at risk for toxic stress can lead to detectable changes in biomarkers, behavior, or health outcomes for children and/or caregivers.
Primary Outcome
Determine the best format of screening either identified (each question individually is answered) vs de-identified (only a total composite score is known) for adverse childhood experiences using the PEARLS (Pediatric Early Adversity and Related Life Advent Screen) tool.
Interventions
- BEHAVIORAL Usual Care
- BEHAVIORAL Care Coordination
- BEHAVIORAL Resiliency Clinic
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 555 participants |
| Start Date | 2017-03-17 |
| Est. Completion | 2019-12-23 |
| Phase | NA |
What the finished NCT04182906 record still lists
NCT04182906 is an interventional study that assigns participants to a tested intervention. The registered 555 participants enrollment target is mid-sized for trials with a published cap, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (60% lower).
The record links to 0 conditions, and to 3 interventions - of which Usual Care is the first listed.
NCT04182906 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04182906 about?
NCT04182906 is a clinical study titled "Pediatric ACEs Screening and Resiliency Study". Stressful and traumatic experiences in childhood (Adverse Childhood Events, or ACEs) have been associated with poor health outcomes that extend into adulthood. When stress is sustained or severe in the absence of an adequate buffer, the stress response can become dysregulated--a state referred to as...
What is the current status of trial NCT04182906?
This trial is currently completed. It is a NA study. The enrollment target is 555 participants. The study started on 2017-03-17. Estimated completion is 2019-12-23.
What interventions are being tested in trial NCT04182906?
The interventions under investigation include: Usual Care (BEHAVIORAL), Care Coordination (BEHAVIORAL), Resiliency Clinic (BEHAVIORAL).
Who is sponsoring clinical trial NCT04182906?
This trial is sponsored by UCSF Benioff Children's Hospital Oakland, which has 52 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT04182906's enrollment target sits among peer trials
555 184th of 2000 higher than 1,817 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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