Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT04182126 · ClinicalTrials.gov registry record · NA
Adaptive Interventions for Optimizing Malaria Control: a Cluster-Randomized SMART Trial
A NA study, sponsored by University of California, Irvine.
- Completed
- Registry status
- NA
- Development phase
- 122,872
- Enrollment target
NCT04182126: Completed NA study, sponsored by University of California, Irvine.
NCT04182126 is a NA study that has completed, run by University of California, Irvine. The registered enrollment target is 122,872 participants, above the 1,402-participant average among 58,714 other NA trials with a reported enrollment target (8664% higher). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04182126, a NA study, has completed, sponsored by University of California, Irvine.
- COMPLETED
- Registry status
- NA
- Development phase
- 122,872 participants
- Enrollment target
Study Summary
In the past decade, massive scale-up of long-lasting insecticidal nets (LLINs) and indoor residual spraying (IRS) have led to significant reductions in malaria mortality and morbidity. Nonetheless, malaria burden remains high, and a dozen countries in Africa show a trend of increasing malaria incidence over the past several years. The high malaria burden in many areas of Africa underscores the need to improve the effectiveness of intervention tools by optimizing first-line intervention tools and integrating newly approved products into control programs. Vector control is an important component of the national malaria control strategy in Africa. Because transmission settings and vector ecology vary among countries or among districts within a country, interventions that work in one setting may not work well in all settings. Malaria interventions should be adapted and re-adapted over time in response to evolving malaria risks and changing vector ecology and behavior. The central objective of this application is to design optimal adaptive combinations of vector control interventions to maximize reductions in malaria burden based on local malaria transmission risks, changing vector ecology, and available mix of interventions approved by the Ministry of Health in each target country. The central hypothesis is that an adaptive approach based on local malaria risk and changing vector ecology will lead to significant reductions in malaria incidence and transmission risk. The aim of this study is to use a cluster-randomized sequential, multiple assignment randomized trial (SMART) design to compare various vector control methods implemented by the Ministry of Health of Kenya in reducing malaria incidence and infection, and develop an optimal intervention strategy tailored toward to local epidemiological and vector conditions.
Primary Outcome
To compare clinical malaria incidence rates among different intervention arms
Interventions
- OTHER Regular long-lasting insecticidal nets
- OTHER LLIN plus Piperonyl butoxide-treated LLIN
- OTHER Long-lasting microbial larvicide
- OTHER Indoor residual spraying with micro-encapsulated pirimiphos-methyl or other insecticides
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 122,872 participants |
| Start Date | 2019-12-01 |
| Est. Completion | 2024-08-31 |
| Phase | NA |
What the finished NCT04182126 record still lists
NCT04182126 is an interventional study that assigns participants to a tested intervention. Its 122,872 participants enrollment target places it among the larger protocols in the corpus, above the 1,402-participant average among 58,714 other NA trials with a reported enrollment target (8664% higher).
The record links to 0 conditions, and to 4 interventions - of which Regular long-lasting insecticidal nets is the first listed.
NCT04182126 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04182126 about?
NCT04182126 is a clinical study titled "Adaptive Interventions for Optimizing Malaria Control: a Cluster-Randomized SMART Trial". In the past decade, massive scale-up of long-lasting insecticidal nets (LLINs) and indoor residual spraying (IRS) have led to significant reductions in malaria mortality and morbidity. Nonetheless, malaria burden remains high, and a dozen countries in Africa show a trend of increasing malaria incide...
What is the current status of trial NCT04182126?
This trial is currently completed. It is a NA study. The enrollment target is 122,872 participants. The study started on 2019-12-01. Estimated completion is 2024-08-31.
What interventions are being tested in trial NCT04182126?
The interventions under investigation include: Regular long-lasting insecticidal nets (OTHER), LLIN plus Piperonyl butoxide-treated LLIN (OTHER), Long-lasting microbial larvicide (OTHER), Indoor residual spraying with micro-encapsulated pirimiphos-methyl or other insecticides (OTHER).
Who is sponsoring clinical trial NCT04182126?
This trial is sponsored by University of California, Irvine, which has 368 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT04182126's enrollment target sits among peer trials
122,872 2nd of 2000 the highest of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT03897374 · 120,000 participants
Strategic Targeting for Optimal Prevention of Cancer
- NCT06608758 · 120,000 participants
End Diagnostic Overshadowing:Addressing Ableism in Diagnoses
- NCT06251323 · 119,680 participants · NA
Implementing Scalable, PAtient-centered, Team-based, Technology-enabled Care for Adults With Type 2 Diabetes (iPATH)
- NCT02693509 · 128,026 participants
Get With The Guidelines-Heart Failure Registry
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI