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NCT04182126 · ClinicalTrials.gov registry record · NA
Adaptive Interventions for Optimizing Malaria Control: a Cluster-Randomized SMART Trial
A NA study, sponsored by University of California, Irvine.
- Completed
- Registry status
- NA
- Development phase
- 122,872
- Enrollment target
NCT04182126 is a NA study that has completed, run by University of California, Irvine. The registered enrollment target is 122,872 participants.
The verdict
NCT04182126, a NA study, has completed, sponsored by University of California, Irvine.
- COMPLETED
- Registry status
- NA
- Development phase
- 122,872 participants
- Enrollment target
Study Summary
In the past decade, massive scale-up of long-lasting insecticidal nets (LLINs) and indoor residual spraying (IRS) have led to significant reductions in malaria mortality and morbidity. Nonetheless, malaria burden remains high, and a dozen countries in Africa show a trend of increasing malaria incidence over the past several years. The high malaria burden in many areas of Africa underscores the need to improve the effectiveness of intervention tools by optimizing first-line intervention tools and integrating newly approved products into control programs. Vector control is an important component of the national malaria control strategy in Africa. Because transmission settings and vector ecology vary among countries or among districts within a country, interventions that work in one setting may not work well in all settings. Malaria interventions should be adapted and re-adapted over time in response to evolving malaria risks and changing vector ecology and behavior. The central objective of this application is to design optimal adaptive combinations of vector control interventions to maximize reductions in malaria burden based on local malaria transmission risks, changing vector ecology, and available mix of interventions approved by the Ministry of Health in each target country. The central hypothesis is that an adaptive approach based on local malaria risk and changing vector ecology will lead to significant reductions in malaria incidence and transmission risk. The aim of this study is to use a cluster-randomized sequential, multiple assignment randomized trial (SMART) design to compare various vector control methods implemented by the Ministry of Health of Kenya in reducing malaria incidence and infection, and develop an optimal intervention strategy tailored toward to local epidemiological and vector conditions.
Interventions
- OTHER Regular long-lasting insecticidal nets
- OTHER LLIN plus Piperonyl butoxide-treated LLIN
- OTHER Long-lasting microbial larvicide
- OTHER Indoor residual spraying with micro-encapsulated pirimiphos-methyl or other insecticides
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 122,872 participants |
| Start Date | 2019-12-01 |
| Est. Completion | 2024-08-31 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04182126
The ClinicalTrials.gov registry entry for NCT04182126 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 122,872 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University of California, Irvine, which has 368 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 4 interventions - of which Regular long-lasting insecticidal nets is the first listed.
NCT04182126 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT04182126 about?
NCT04182126 is a clinical study titled "Adaptive Interventions for Optimizing Malaria Control: a Cluster-Randomized SMART Trial". In the past decade, massive scale-up of long-lasting insecticidal nets (LLINs) and indoor residual spraying (IRS) have led to significant reductions in malaria mortality and morbidity. Nonetheless, malaria burden remains high, and a dozen countries in Africa show a trend of increasing malaria incide...
What is the current status of trial NCT04182126?
This trial is currently completed. It is a NA study. The enrollment target is 122,872 participants. The study started on 2019-12-01. Estimated completion is 2024-08-31.
What interventions are being tested in trial NCT04182126?
The interventions under investigation include: Regular long-lasting insecticidal nets (OTHER), LLIN plus Piperonyl butoxide-treated LLIN (OTHER), Long-lasting microbial larvicide (OTHER), Indoor residual spraying with micro-encapsulated pirimiphos-methyl or other insecticides (OTHER).
Who is sponsoring clinical trial NCT04182126?
This trial is sponsored by University of California, Irvine, which has 368 total clinical trials registered on ClinicalTrials.gov.
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