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ACTIVE NOT RECRUITING Phase 3

Extension Study to Assess Effects of Non-interrupted Versus Interrupted and Long Term Treatment of Two Dose Regimes of Secukinumab in Subjects With Hidradenitis Suppurativa

NCT04179175 · View on ClinicalTrials.gov ↗

Study Summary

The purpose of this extension study is to evaluate maintenance of Hidradenitis Suppurativa Clinical Response (HiSCR response) in either continuous or interrupted therapy (using a randomized withdrawal period) of two dose regimens and to assess long-term efficacy, safety and tolerability of Secukinumab in subjects with moderate to severe hidradenitis suppurativa completing either of the 2 Phase III studies. This is an expanded access trial for the core trials CAIN457M2301 (NCT03713619) and CAIN457M2302 (NCT03713619).

Conditions Studied

Interventions

  • DRUG secukinumab

Study Locations (20)

Florida

  • Florida Academic Centers Research and Education LLC — Coral Gables
  • University of MiamiHealth System — Miami
  • Olympian Clinical Research — Tampa
  • University Of South Florida — Tampa

California

  • MedDerm Associates — San Diego
  • University Clinical Trials — San Diego
  • Southern California Skin and Laser — Whittier

Missouri

  • MediSearch Clinical Trials — Saint Joseph
  • St Louis U Clinical Trials — St Louis
  • WA Uni School Of Med — St Louis

Illinois

  • Endeavor Health — Glenview
  • Dundee Dermatology — West Dundee

Massachusetts

  • Tufts Medical Center — Boston
  • Beth Israel Deaconess Med Center — Boston

Arkansas

  • Northwest Arkansas Center — Rogers

Georgia

  • Advanced Medical Research — Sandy Springs

Indiana

  • Dawes Fretzin Clinical Rea Group — Indianapolis

Trial Details

FieldValue
Enrollment Target 703 participants
Start Date 2020-03-18
Est. Completion 2026-07-15
Phase Phase 3

Sponsor

Novartis Pharmaceuticals

792 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT04179175

The ClinicalTrials.gov registry entry for NCT04179175 describes a study currently listed as active not recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 703 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Novartis Pharmaceuticals, which has 792 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Hidradenitis Suppurativa appearing as the primary indexed condition, and to 1 intervention — of which secukinumab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT04179175 reports 20 study locations spanning 11 distinct geographic areas — top geographies include Florida, California, Missouri. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT04179175 about?

NCT04179175 is a clinical study titled "Extension Study to Assess Effects of Non-interrupted Versus Interrupted and Long Term Treatment of Two Dose Regimes of Secukinumab in Subjects With Hidradenitis Suppurativa". The purpose of this extension study is to evaluate maintenance of Hidradenitis Suppurativa Clinical Response (HiSCR response) in either continuous or interrupted therapy (using a randomized withdrawal period) of two dose regimens and to assess long-term efficacy, safety and tolerability of Secukinum...

What is the current status of trial NCT04179175?

This trial is currently active not recruiting. It is a Phase 3 study. The enrollment target is 703 participants. The study started on 2020-03-18. Estimated completion is 2026-07-15.

What conditions does trial NCT04179175 study?

This clinical trial studies the following conditions: Hidradenitis Suppurativa. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT04179175?

The interventions under investigation include: secukinumab (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT04179175?

This trial is sponsored by Novartis Pharmaceuticals, which has 792 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT04179175 being conducted?

This trial has 20 study locations across Arkansas, California, Florida, Georgia, Illinois. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial