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NCT04176406 · ClinicalTrials.gov registry record · NA
Using fMRI-guided TMS to Increase Central Executive Function in Older Adults (MCI_Sub)
A NA study, sponsored by Duke University.
- Terminated
- Registry status
- NA
- Development phase
- 10
- Enrollment target
NCT04176406: Clinical Trial NA study, sponsored by Duke University.
NCT04176406 is a NA study that was terminated before completion, run by Duke University. The registered enrollment target is 10 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04176406, a NA study, was terminated before completion, sponsored by Duke University.
- TERMINATED
- Registry status
- NA
- Development phase
- 10 participants
- Enrollment target
Study Summary
This is an administrative supplement to an existing project "Using fMRI-guided TMS to increase central executive function in older adults: NCT02767323" This award allows extending our existing fMRI-TMS paradigm to patients with a prodromal form of Alzheimer's Disease (AD) known as amnestic Mild Cognitive Impairment (MCI), and investigate the role of brain health factors in mediating the TMS-related memory performance benefits associated with communication between a network of frontoparietal brain regions in these populations. The focus on focal neurostimulation at only a single site represents a fundamental gap in the approach of memory-based neurostimulation therapies. Neurostimulation affects multiple sites within a cortical network, but these global effects have not been used as targets for stimulation because of limited knowledge about what influence these localized sites have on global changes in brain state. To address this problem, multimodal neuroimaging tools and network modeling approaches developed though the parent U01 project will be used, to demonstrate how focal neurostimulation improves the efficacy of TMS for enhancing memory function. These goals will be addressed in the Administrative Supplement under our two specific aims. First, network-guided TMS will be applied to optimize memory success based in the frontoparietal network (FPN) in a new group of MCI patients. A new form of TMS targeting that involves modeling of the global network to understand how the controllability of a stimulation site evokes changes in widespread brain networks will be tested. Second, structural and functional factors affecting the efficacy of individualized network-guided TMS will be identified to ameliorate deficits in MCI. By creating a multimodal model of neural deficits related to MCI, network-guided TMS will be adjusted to demonstrate how the MCI brain might compensate for these neural deficits. The parent U01 project has made foundational advances towards these g
Primary Outcome
Accuracy (in percentage) will be assessed to evaluate the acute effect of rTMS.
Interventions
- DEVICE Sham rTMS
- DEVICE rTMS
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 10 participants |
| Start Date | 2019-11-25 |
| Est. Completion | 2020-02-27 |
| Phase | NA |
Why NCT04176406 stopped before completion
NCT04176406 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 10 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower).
The record links to 0 conditions, and to 2 interventions - of which Sham rTMS is the first listed.
NCT04176406 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04176406 about?
NCT04176406 is a clinical study titled "Using fMRI-guided TMS to Increase Central Executive Function in Older Adults (MCI_Sub)". This is an administrative supplement to an existing project "Using fMRI-guided TMS to increase central executive function in older adults: NCT02767323" This award allows extending our existing fMRI-TMS paradigm to patients with a prodromal form of Alzheimer's Disease (AD) known as amnestic Mild Cogn...
What is the current status of trial NCT04176406?
This trial is currently terminated. It is a NA study. The enrollment target is 10 participants. The study started on 2019-11-25. Estimated completion is 2020-02-27.
What interventions are being tested in trial NCT04176406?
The interventions under investigation include: Sham rTMS (DEVICE), rTMS (DEVICE).
Who is sponsoring clinical trial NCT04176406?
This trial is sponsored by Duke University, which has 1,725 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT04176406's enrollment target sits among peer trials
10 1927th of 2000 higher than 26 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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