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NCT04176406 · ClinicalTrials.gov registry record · NA
Using fMRI-guided TMS to Increase Central Executive Function in Older Adults (MCI_Sub)
A NA study, sponsored by Duke University.
- Terminated
- Registry status
- NA
- Development phase
- 10
- Enrollment target
NCT04176406 is a NA study that was terminated before completion, run by Duke University. The registered enrollment target is 10 participants.
The verdict
NCT04176406, a NA study, was terminated before completion, sponsored by Duke University.
- TERMINATED
- Registry status
- NA
- Development phase
- 10 participants
- Enrollment target
Study Summary
This is an administrative supplement to an existing project "Using fMRI-guided TMS to increase central executive function in older adults: NCT02767323" This award allows extending our existing fMRI-TMS paradigm to patients with a prodromal form of Alzheimer's Disease (AD) known as amnestic Mild Cognitive Impairment (MCI), and investigate the role of brain health factors in mediating the TMS-related memory performance benefits associated with communication between a network of frontoparietal brain regions in these populations. The focus on focal neurostimulation at only a single site represents a fundamental gap in the approach of memory-based neurostimulation therapies. Neurostimulation affects multiple sites within a cortical network, but these global effects have not been used as targets for stimulation because of limited knowledge about what influence these localized sites have on global changes in brain state. To address this problem, multimodal neuroimaging tools and network modeling approaches developed though the parent U01 project will be used, to demonstrate how focal neurostimulation improves the efficacy of TMS for enhancing memory function. These goals will be addressed in the Administrative Supplement under our two specific aims. First, network-guided TMS will be applied to optimize memory success based in the frontoparietal network (FPN) in a new group of MCI patients. A new form of TMS targeting that involves modeling of the global network to understand how the controllability of a stimulation site evokes changes in widespread brain networks will be tested. Second, structural and functional factors affecting the efficacy of individualized network-guided TMS will be identified to ameliorate deficits in MCI. By creating a multimodal model of neural deficits related to MCI, network-guided TMS will be adjusted to demonstrate how the MCI brain might compensate for these neural deficits. The parent U01 project has made foundational advances towards these g
Interventions
- DEVICE Sham rTMS
- DEVICE rTMS
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 10 participants |
| Start Date | 2019-11-25 |
| Est. Completion | 2020-02-27 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04176406
The ClinicalTrials.gov registry entry for NCT04176406 describes a study currently listed as terminated, categorized as NA. The registered enrollment target is 10 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Duke University, which has 1,725 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 2 interventions - of which Sham rTMS is the first listed.
NCT04176406 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT04176406 about?
NCT04176406 is a clinical study titled "Using fMRI-guided TMS to Increase Central Executive Function in Older Adults (MCI_Sub)". This is an administrative supplement to an existing project "Using fMRI-guided TMS to increase central executive function in older adults: NCT02767323" This award allows extending our existing fMRI-TMS paradigm to patients with a prodromal form of Alzheimer's Disease (AD) known as amnestic Mild Cogn...
What is the current status of trial NCT04176406?
This trial is currently terminated. It is a NA study. The enrollment target is 10 participants. The study started on 2019-11-25. Estimated completion is 2020-02-27.
What interventions are being tested in trial NCT04176406?
The interventions under investigation include: Sham rTMS (DEVICE), rTMS (DEVICE).
Who is sponsoring clinical trial NCT04176406?
This trial is sponsored by Duke University, which has 1,725 total clinical trials registered on ClinicalTrials.gov.
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