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NCT04156906 · ClinicalTrials.gov registry record · Early Phase 1
RHD Genotype Matched Red Cells for Anti-D
A Early Phase 1 study, sponsored by Children's Hospital of Philadelphia.
- Completed
- Registry status
- Early Phase 1
- Development phase
- 5
- Enrollment target
NCT04156906: Completed Early Phase 1 study, sponsored by Children's Hospital of Philadelphia.
NCT04156906 is a Early Phase 1 study that has completed, run by Children's Hospital of Philadelphia. The registered enrollment target is 5 participants, below the 53-participant average among 2,764 other Early Phase 1 trials with a reported enrollment target (91% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04156906, a Early Phase 1 study, has completed, sponsored by Children's Hospital of Philadelphia.
- COMPLETED
- Registry status
- Early Phase 1
- Development phase
- 5 participants
- Enrollment target
Study Summary
This is a pilot study to evaluate the feasibility and safety of providing RH genotype matched D+ Red Blood Cells (RBCs) to chronically transfused patients with sickle cell disease (SCD) who type D+ but have formed anti-D and are currently transfused with D- RBC (Red Blood Cell) units.
Primary Outcome
To determine safety of providing RH genotype match red cells to patients with a history of anti-D, we observed if anti-D reappearance occurred or evidence of hemolysis of transfused red cells.
Interventions
- BIOLOGICAL D+ RH genotype matched red cell units for transfusion
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 5 participants |
| Start Date | 2020-07-08 |
| Est. Completion | 2024-10-04 |
| Phase | Early Phase 1 |
What the finished NCT04156906 record still lists
NCT04156906 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 5 participants, a relatively small participant target, below the 53-participant average among 2,764 other Early Phase 1 trials with a reported enrollment target (91% lower).
The record links to 0 conditions, and to 1 intervention - of which D+ RH genotype matched red cell units for transfusion is the first listed.
NCT04156906 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04156906 about?
NCT04156906 is a clinical study titled "RHD Genotype Matched Red Cells for Anti-D". This is a pilot study to evaluate the feasibility and safety of providing RH genotype matched D+ Red Blood Cells (RBCs) to chronically transfused patients with sickle cell disease (SCD) who type D+ but have formed anti-D and are currently transfused with D- RBC (Red Blood Cell) units.
What is the current status of trial NCT04156906?
This trial is currently completed. It is a Early Phase 1 study. The enrollment target is 5 participants. The study started on 2020-07-08. Estimated completion is 2024-10-04.
What interventions are being tested in trial NCT04156906?
The interventions under investigation include: D+ RH genotype matched red cell units for transfusion (BIOLOGICAL).
Who is sponsoring clinical trial NCT04156906?
This trial is sponsored by Children's Hospital of Philadelphia, which has 431 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT04156906's enrollment target sits among peer trials
5 1887th of 2000 higher than 80 of 2,000 other Early Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Early Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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