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NCT04140708 · ClinicalTrials.gov registry record · NA
Effects of Exercise on Glymphatic Functioning and Neurobehavioral Correlates in Parkinson's Disease
A NA study, sponsored by Vanderbilt University Medical Center.
- Completed
- Registry status
- NA
- Development phase
- 37
- Enrollment target
NCT04140708: Completed NA study, sponsored by Vanderbilt University Medical Center.
NCT04140708 is a NA study that has completed, run by Vanderbilt University Medical Center. The registered enrollment target is 37 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (97% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04140708, a NA study, has completed, sponsored by Vanderbilt University Medical Center.
- COMPLETED
- Registry status
- NA
- Development phase
- 37 participants
- Enrollment target
Study Summary
This study is designed to measure the change in patients diagnosed with Parkinson's disease (PD) before, during and after a 12 week exercise program.The focus of this study is the glymphatic system. The glymphatic system is a recentlydiscovered novel waste clearance pathway, in patients with Parkinson's Disease (PD).The glymphatic system acts as a waste-clearance system in the brain of vertebrate animals.The glymphatic system has been proposed in which new clearance pathways involving communication between paravascular spaces, interstitial fluid, and ultimately meningeal and dural lymphatic vessels exists, and we have provided evidence that this system may be dysfunctional in patients with Parkinson's disease with cognitive disorders. Early research suggest glymphatic function increases following exercise, this response is believed to clear beta-amyloid in the brain and may mediate the neurobehavioral response to exercise in PD. This study will use cognitive exams, neurological exams as well as specialized imaging to record data points and evaluate the glymphatic function after exercise.
Primary Outcome
Using MRI/PET scans to measure change from baseline to followup of beta-amyloid levels
Interventions
- BEHAVIORAL Exercise--Rock Steady Boxing class
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 37 participants |
| Start Date | 2019-11-22 |
| Est. Completion | 2023-09-05 |
| Phase | NA |
What the finished NCT04140708 record still lists
NCT04140708 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 37 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (97% lower).
The record links to 0 conditions, and to 1 intervention - of which Exercise--Rock Steady Boxing class is the first listed.
NCT04140708 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04140708 about?
NCT04140708 is a clinical study titled "Effects of Exercise on Glymphatic Functioning and Neurobehavioral Correlates in Parkinson's Disease". This study is designed to measure the change in patients diagnosed with Parkinson's disease (PD) before, during and after a 12 week exercise program.The focus of this study is the glymphatic system. The glymphatic system is a recentlydiscovered novel waste clearance pathway, in patients with Parkins...
What is the current status of trial NCT04140708?
This trial is currently completed. It is a NA study. The enrollment target is 37 participants. The study started on 2019-11-22. Estimated completion is 2023-09-05.
What interventions are being tested in trial NCT04140708?
The interventions under investigation include: Exercise--Rock Steady Boxing class (BEHAVIORAL).
Who is sponsoring clinical trial NCT04140708?
This trial is sponsored by Vanderbilt University Medical Center, which has 677 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT04140708's enrollment target sits among peer trials
37 1540th of 2000 higher than 460 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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