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NCT04140292 · ClinicalTrials.gov registry record · Phase 2
Vitamin D Supplementation as a Neoadjuvant for Photodynamic Therapy of Actinic Keratoses
A Phase 2 study, sponsored by Case Comprehensive Cancer Center.
- Completed
- Registry status
- Phase 2
- Development phase
- 75
- Enrollment target
NCT04140292: Completed Phase 2 study, sponsored by Case Comprehensive Cancer Center.
NCT04140292 is a Phase 2 study that has completed, run by Case Comprehensive Cancer Center. The registered enrollment target is 75 participants, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (44% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04140292, a Phase 2 study, has completed, sponsored by Case Comprehensive Cancer Center.
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 75 participants
- Enrollment target
Study Summary
This study is open to individuals with Actinic Keratoses (skin lesions that have the potential to turn into skin cancer), who are receiving photodynamic therapy (PDT) as part of their clinical care. The purpose of this study is to test and demonstrate that vitamin D pre-treatment can enhance PDT efficacy in the treatment of Actinic Keratoses. Participants will be asked to take vitamin D supplements prior to their standard of care PDT treatment. Participation in the research will last about 3-4 months.
Primary Outcome
Clinical PDT response as measured by the percent change of AK lesions 3 months after treatment Baseline vitamin D (calcidiol) level will be taken for each patient.
Interventions
- DRUG Vitamin D3
- DRUG Photodynamic therapy (PDT)
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 75 participants |
| Start Date | 2020-01-13 |
| Est. Completion | 2021-05-27 |
| Phase | Phase 2 |
What the finished NCT04140292 record still lists
NCT04140292 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 75 participants, a relatively small participant target, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (44% lower).
The record links to 0 conditions, and to 2 interventions - of which Vitamin D3 is the first listed.
NCT04140292 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04140292 about?
NCT04140292 is a clinical study titled "Vitamin D Supplementation as a Neoadjuvant for Photodynamic Therapy of Actinic Keratoses". This study is open to individuals with Actinic Keratoses (skin lesions that have the potential to turn into skin cancer), who are receiving photodynamic therapy (PDT) as part of their clinical care. The purpose of this study is to test and demonstrate that vitamin D pre-treatment can enhance PDT eff...
What is the current status of trial NCT04140292?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 75 participants. The study started on 2020-01-13. Estimated completion is 2021-05-27.
What interventions are being tested in trial NCT04140292?
The interventions under investigation include: Vitamin D3 (DRUG), Photodynamic therapy (PDT) (DRUG).
Who is sponsoring clinical trial NCT04140292?
This trial is sponsored by Case Comprehensive Cancer Center, which has 407 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT04140292's enrollment target sits among peer trials
75 900th of 2000 higher than 1,081 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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