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NCT04134845 · ClinicalTrials.gov registry record · Phase 2
A Clinical Trial Utilizing Dantrolene in Patients With Ventricular Arrhythmias.
A Phase 2 study of Ventricular Tachycardia, sponsored by Vanderbilt University Medical Center.
- Completed
- Registry status
- Phase 2
- Development phase
- 68
- Enrollment target
- 1
- Study location
NCT04134845: Completed Phase 2 study of Ventricular Tachycardia, sponsored by Vanderbilt University Medical Center.
NCT04134845 is a Phase 2 study of Ventricular Tachycardia that has completed, run by Vanderbilt University Medical Center. The registered enrollment target is 68 participants, below the 286-participant average among 28 other Ventricular Tachycardia trials with a reported enrollment target (76% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04134845, a Phase 2 study of Ventricular Tachycardia, has completed, sponsored by Vanderbilt University Medical Center.
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 68 participants
- Enrollment target
- 1
- Study location
Study Summary
This is a randomized, placebo-controlled trial of Dantrolene (N= 84 participants) to demonstrate the feasibility of using intravenous (IV) dantrolene to study the effect of RyR2 inhibition on cardiac electrophysiology, hemodynamics, and ventricular arrhythmia inducibility in patients with structural heart disease referred for Ventricular Tachycardia (VT) ablation. The investigators will also explore the pharmacokinetic/pharmacodynamic relationship of IV dantrolene and its short-term effect on specific cardiac electrophysiologic and hemodynamic parameters.
Primary Outcome
Post drug ventricular stimulation with Right Ventricle (RV) ventricular catheter in the Right Ventricle( RV) apex with increasing extra stimuli with planned decrement stimuli by 10 milliseconds (ms) to effective refractory period (ERP). Outcome is measured as Ventricular inducibility yes/no.
Conditions Studied
Interventions
- DRUG Placebo
- DRUG Dantrolene/Ryanodex
Study Locations (1)
Tennessee
- Vanderbilt University Medical Center - Nashville
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 68 participants |
| Start Date | 2020-08-21 |
| Est. Completion | 2025-08-29 |
| Phase | Phase 2 |
What the finished NCT04134845 record still lists
NCT04134845 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 68 participants, a relatively small participant target, below the 286-participant average among 28 other Ventricular Tachycardia trials with a reported enrollment target (76% lower).
The record links to 1 condition, with Ventricular Tachycardia appearing as the primary indexed condition, and to 2 interventions - of which Placebo is the first listed.
NCT04134845 reports a single indexed study location in Tennessee.
Frequently Asked Questions
What is clinical trial NCT04134845 about?
NCT04134845 is a clinical study titled "A Clinical Trial Utilizing Dantrolene in Patients With Ventricular Arrhythmias.". This is a randomized, placebo-controlled trial of Dantrolene (N= 84 participants) to demonstrate the feasibility of using intravenous (IV) dantrolene to study the effect of RyR2 inhibition on cardiac electrophysiology, hemodynamics, and ventricular arrhythmia inducibility in patients with structural...
What is the current status of trial NCT04134845?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 68 participants. The study started on 2020-08-21. Estimated completion is 2025-08-29.
What conditions does trial NCT04134845 study?
This clinical trial studies the following conditions: Ventricular Tachycardia.
What interventions are being tested in trial NCT04134845?
The interventions under investigation include: Placebo (DRUG), Dantrolene/Ryanodex (DRUG).
Who is sponsoring clinical trial NCT04134845?
This trial is sponsored by Vanderbilt University Medical Center, which has 677 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04134845 being conducted?
This trial has 1 study location across Tennessee. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Ventricular Tachycardia
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04134845's enrollment target sits among peer trials
68 18th of 28 higher than 11 of 28 other Ventricular Tachycardia trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Ventricular Tachycardia trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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