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NCT04134845 · ClinicalTrials.gov registry record · Phase 2

A Clinical Trial Utilizing Dantrolene in Patients With Ventricular Arrhythmias.

A Phase 2 study of Ventricular Tachycardia, sponsored by Vanderbilt University Medical Center.

Completed
Registry status
Phase 2
Development phase
68
Enrollment target
1
Study location

NCT04134845 is a Phase 2 study of Ventricular Tachycardia that has completed, run by Vanderbilt University Medical Center. The registered enrollment target is 68 participants, below the 286-participant average among 28 other Ventricular Tachycardia trials with a reported enrollment target (76% lower). The trial reports 1 study location across 1 state.

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The verdict

NCT04134845, a Phase 2 study of Ventricular Tachycardia, has completed, sponsored by Vanderbilt University Medical Center.

COMPLETED
Registry status
Phase 2
Development phase
68 participants
Enrollment target
1
Study location

Study Summary

This is a randomized, placebo-controlled trial of Dantrolene (N= 84 participants) to demonstrate the feasibility of using intravenous (IV) dantrolene to study the effect of RyR2 inhibition on cardiac electrophysiology, hemodynamics, and ventricular arrhythmia inducibility in patients with structural heart disease referred for Ventricular Tachycardia (VT) ablation. The investigators will also explore the pharmacokinetic/pharmacodynamic relationship of IV dantrolene and its short-term effect on specific cardiac electrophysiologic and hemodynamic parameters.

Conditions Studied

Ventricular Tachycardia

Interventions

  • DRUG Placebo
  • DRUG Dantrolene/Ryanodex

Study Locations (1)

Tennessee

  • Vanderbilt University Medical Center - Nashville

Trial Details

FieldValue
Enrollment Target 68 participants
Start Date 2020-08-21
Est. Completion 2025-08-29
Phase Phase 2

Sponsor

Vanderbilt University Medical Center

677 total trials

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What the Registry Record Tells You About NCT04134845

The ClinicalTrials.gov registry entry for NCT04134845 describes a study currently listed as completed, categorized as Phase 2. The registered enrollment target is 68 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 286-participant average among 28 other Ventricular Tachycardia trials with a reported enrollment target (76% lower). The listed sponsor is Vanderbilt University Medical Center, which has 677 total studies on file at ClinicalTrials.gov.

The record links to 1 condition, with Ventricular Tachycardia appearing as the primary indexed condition, and to 2 interventions - of which Placebo is the first listed.

NCT04134845 reports 1 study location spanning 1 distinct geographic area - top geographies include Tennessee.

Frequently Asked Questions

What is clinical trial NCT04134845 about?

NCT04134845 is a clinical study titled "A Clinical Trial Utilizing Dantrolene in Patients With Ventricular Arrhythmias.". This is a randomized, placebo-controlled trial of Dantrolene (N= 84 participants) to demonstrate the feasibility of using intravenous (IV) dantrolene to study the effect of RyR2 inhibition on cardiac electrophysiology, hemodynamics, and ventricular arrhythmia inducibility in patients with structural...

What is the current status of trial NCT04134845?

This trial is currently completed. It is a Phase 2 study. The enrollment target is 68 participants. The study started on 2020-08-21. Estimated completion is 2025-08-29.

What conditions does trial NCT04134845 study?

This clinical trial studies the following conditions: Ventricular Tachycardia.

What interventions are being tested in trial NCT04134845?

The interventions under investigation include: Placebo (DRUG), Dantrolene/Ryanodex (DRUG).

Who is sponsoring clinical trial NCT04134845?

This trial is sponsored by Vanderbilt University Medical Center, which has 677 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT04134845 being conducted?

This trial has 1 study location across Tennessee. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.