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Ablation-Index Guided Scar-Mediated Ventricular Tachycardia Ablation in Patients With Ischemic Cardiomyopathy
NCT06138873 · View on ClinicalTrials.gov ↗
Study Summary
Over the last decade, radiofrequency catheter ablation (RFCA) has become an established treatment for ventricular arrhythmias (VA). Due to the challenging nature of visualizing lesion formation in real time and ensuring an effective transmural lesion, different surrogate measures of lesion quality have been used. The Ablation Index (AI) is a variable incorporating power delivery in its formula and combining it with CF and time in a weighted equation which aims at allowing for a more precise estimation of lesion depth and quality when ablating VAs. AI guidance has previously been shown to improve outcomes in atrial and ventricular ablation in patients with premature ventricular complexes (PVC). However research on outcomes following AI-guidance for VT ablation specifically in patients with structural disease and prior myocardial infarction remains sparse. The investigators aim at conducting the first randomized controlled trial testing for the superiority of an AI-guided approach regarding procedural duration.
Conditions Studied
Interventions
- PROCEDURE Ablation-index guided ventricular tachycardia ablation
- PROCEDURE Ventricular tachycardia ablation with no AI-guidance
Study Locations (5)
Illinois
- Rush University Medical Center — Chicago
Massachusetts
- Mass General Brigham and Women's Hospital — Boston
Michigan
- Medical University of Michigan — Ann Arbor
Minnesota
- Mayo Clinic — Rochester
South Carolina
- Medical University of South Carolina — Charleston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 100 participants |
| Start Date | 2024-10-23 |
| Est. Completion | 2027-11-23 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06138873
The ClinicalTrials.gov registry entry for NCT06138873 describes a study currently listed as recruiting. It is categorized as NA, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 100 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Rush University Medical Center, which has 168 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 2 conditions, with Ventricular Tachycardia appearing as the primary indexed condition, and to 2 interventions — of which Ablation-index guided ventricular tachycardia ablation is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT06138873 reports 5 study locations spanning 5 distinct geographic areas — top geographies include Illinois, Massachusetts, Michigan. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT06138873 about?
NCT06138873 is a clinical study titled "Ablation-Index Guided Scar-Mediated Ventricular Tachycardia Ablation in Patients With Ischemic Cardiomyopathy". Over the last decade, radiofrequency catheter ablation (RFCA) has become an established treatment for ventricular arrhythmias (VA). Due to the challenging nature of visualizing lesion formation in real time and ensuring an effective transmural lesion, different surrogate measures of lesion quality h...
What is the current status of trial NCT06138873?
This trial is currently recruiting. It is a NA study. The enrollment target is 100 participants. The study started on 2024-10-23. Estimated completion is 2027-11-23.
What conditions does trial NCT06138873 study?
This clinical trial studies the following conditions: Ventricular Tachycardia, Ischemic Cardiomyopathy. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT06138873?
The interventions under investigation include: Ablation-index guided ventricular tachycardia ablation (PROCEDURE), Ventricular tachycardia ablation with no AI-guidance (PROCEDURE). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT06138873?
This trial is sponsored by Rush University Medical Center, which has 168 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT06138873 being conducted?
This trial has 5 study locations across Illinois, Massachusetts, Michigan, Minnesota, South Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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