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NCT04125238 · ClinicalTrials.gov registry record · NA
Increasing the Temporal Window in Individuals With Alcohol Use Disorder
A NA study, sponsored by Virginia Polytechnic Institute and State University.
- Completed
- Registry status
- NA
- Development phase
- 154
- Enrollment target
NCT04125238 is a NA study that has completed, run by Virginia Polytechnic Institute and State University. The registered enrollment target is 154 participants.
The verdict
NCT04125238, a NA study, has completed, sponsored by Virginia Polytechnic Institute and State University.
- COMPLETED
- Registry status
- NA
- Development phase
- 154 participants
- Enrollment target
Study Summary
Episodic future thinking (EFT) is based on the new science of prospection, which was first identified in a Science publication in 2007 and refers to pre-experiencing the future by simulation. Considerable evidence suggests that prospection is important for understanding human cognition, affect, motivation, and action. Individuals with damaged frontal areas, as well as individuals with alcohol use disorder (AUD), show deficits in planning prospectively. One systematic method to engender prospection is via EFT. EFT, as applied in our prior studies and in this proposal consists of having participants develop positive plausible future events that correspond to several future time frames (e.g., 2 weeks, 1 month, 3 months etc). For each of these timeframes participants are asked to concretize the events (e.g., What are you doing? Who will be there? What will you see, hear, smell, and feel?). We and others have used EFT to decrease delay discounting (DD) in individuals with AUD and smokers, as well as normal weight, overweight, and obese populations when compared to the control condition, control episodic thinking (CET). Consistent with reinforcer pathology, EFT also reduces alcohol valuation in the purchase task among individuals with AUD. However, no study to date has examined whether EFT reduces alcohol self-administration in the laboratory. Moreover, the neural correlates of EFT in AUD are also unknown. In these studies, we propose to test an intervention, EFT, which we hypothesize will decrease reinforcer pathology measures in a bar-like setting in the laboratory; that is, EFT will decrease delay discounting, as well as alcohol self-administration, demand, and craving compared to a control episodic thinking (CET) condition. Moreover, we hypothesize EFT will enhance activation in brain regions associated with prospection (e.g., hippocampus and amygdala) and the executive decision system (e.g., DLPFC). We will also examine the effect of EFT on real-world drinking.
Interventions
- BEHAVIORAL Episodic Future Thinking
- BEHAVIORAL Control Episodic Thinking
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 154 participants |
| Start Date | 2020-11-13 |
| Est. Completion | 2024-09-30 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04125238
The ClinicalTrials.gov registry entry for NCT04125238 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 154 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Virginia Polytechnic Institute and State University, which has 104 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 2 interventions - of which Episodic Future Thinking is the first listed.
NCT04125238 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT04125238 about?
NCT04125238 is a clinical study titled "Increasing the Temporal Window in Individuals With Alcohol Use Disorder". Episodic future thinking (EFT) is based on the new science of prospection, which was first identified in a Science publication in 2007 and refers to pre-experiencing the future by simulation. Considerable evidence suggests that prospection is important for understanding human cognition, affect, moti...
What is the current status of trial NCT04125238?
This trial is currently completed. It is a NA study. The enrollment target is 154 participants. The study started on 2020-11-13. Estimated completion is 2024-09-30.
What interventions are being tested in trial NCT04125238?
The interventions under investigation include: Episodic Future Thinking (BEHAVIORAL), Control Episodic Thinking (BEHAVIORAL).
Who is sponsoring clinical trial NCT04125238?
This trial is sponsored by Virginia Polytechnic Institute and State University, which has 104 total clinical trials registered on ClinicalTrials.gov.
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