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NCT04111536 · ClinicalTrials.gov registry record · Phase 1
Developing Oral LT3 Therapy for Heart Failure - HFpEF
A Phase 1 study, sponsored by University of Pennsylvania.
- Completed
- Registry status
- Phase 1
- Development phase
- 28
- Enrollment target
NCT04111536: Completed Phase 1 study, sponsored by University of Pennsylvania.
NCT04111536 is a Phase 1 study that has completed, run by University of Pennsylvania. The registered enrollment target is 28 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (53% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04111536, a Phase 1 study, has completed, sponsored by University of Pennsylvania.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 28 participants
- Enrollment target
Study Summary
Investigation of the safety, feasibility, and preliminary efficacy of thyroid hormone therapy with Liothyronine (LT3) in individuals with heart failure with preserved ejection fraction (HFpEF) and low triiodothyronine (T3) syndrome by conducting a randomized, double-blind, placebo-controlled cross-over study with a two-week washout period between treatments.
Primary Outcome
Number with atrial fibrillation or ventricular tachycardia \>=4 beats
Interventions
- OTHER Placebo
- DRUG liothyronine
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 28 participants |
| Start Date | 2020-03-08 |
| Est. Completion | 2023-10-31 |
| Phase | Phase 1 |
What the finished NCT04111536 record still lists
NCT04111536 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 28 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (53% lower).
The record links to 0 conditions, and to 2 interventions - of which Placebo is the first listed.
NCT04111536 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04111536 about?
NCT04111536 is a clinical study titled "Developing Oral LT3 Therapy for Heart Failure - HFpEF". Investigation of the safety, feasibility, and preliminary efficacy of thyroid hormone therapy with Liothyronine (LT3) in individuals with heart failure with preserved ejection fraction (HFpEF) and low triiodothyronine (T3) syndrome by conducting a randomized, double-blind, placebo-controlled cross-o...
What is the current status of trial NCT04111536?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 28 participants. The study started on 2020-03-08. Estimated completion is 2023-10-31.
What interventions are being tested in trial NCT04111536?
The interventions under investigation include: Placebo (OTHER), liothyronine (DRUG).
Who is sponsoring clinical trial NCT04111536?
This trial is sponsored by University of Pennsylvania, which has 1,423 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT04111536's enrollment target sits among peer trials
28 1447th of 2000 higher than 538 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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