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NCT04110756 · ClinicalTrials.gov registry record · NA

ChangeGradients: Promoting Adolescent Health Behavior Change

A NA study of Cancer and Alcohol Drinking, sponsored by University of California, San Francisco.

Recruiting
Registry status
NA
Development phase
200
Enrollment target
1
Study location

NCT04110756: Recruiting NA study of Cancer and Alcohol Drinking, sponsored by University of California, San Francisco.

NCT04110756 is a NA study of Cancer and Alcohol Drinking that is actively recruiting participants, run by University of California, San Francisco. The registered enrollment target is 200 participants, below the 3,491-participant average among 615 other Cancer trials with a reported enrollment target (94% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.

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The verdict

NCT04110756, a NA study of Cancer and Alcohol Drinking, is actively recruiting participants, sponsored by University of California, San Francisco.

RECRUITING
Registry status
NA
Development phase
200 participants
Enrollment target
1
Study location

Study Summary

As most adolescents visit a healthcare provider once a year, health behavior change interventions linked to clinic-based health information technologies hold significant promise for improving healthcare quality and subsequent behavioral health outcomes for adolescents (Baird, 2014, Harris, 2017). Recognizing the potential to leverage recent advances in machine learning and interactive narrative environments, the investigators are now well positioned to design health behavior change systems that extend the reach of clinicians to realize significant impacts on behavior change for adolescent preventive health. The proposed project centers on the design, development, and evaluation of a clinically-integrated health behavior change system for adolescents. CHANGEGRADIENTS will introduce an innovative reinforcement learning-based feedback loop in which adolescent patients interact with personalized behavior change interactive narratives that are dynamically personalized and realized in a rich narrative-centered virtual environment. CHANGEGRADIENTS will iteratively improve its behavior change models using policy gradient methods for Reinforcement Learning (RL) designed to optimize adolescents' achieved behavior change outcomes. This in turn will enable CHANGEGRADIENTS to generate more effective behavior change narratives, which will then lead to further improved behavior change outcomes. With a focus on risky behaviors and an emphasis on alcohol use, adolescents will interact with CHANGEGRADIENTS to develop an experiential understanding of the dynamics and consequences of their alcohol use decisions. The proposed project holds significant transformative potential for (1) producing theoretical and practical advances in how to realize significant impacts on adolescent health behavior change through novel interactive narrative technologies integrated with policy-based reinforcement learning, (2) devising sample-efficient policy gradient methods for RL that produce personalize

Primary Outcome

Standard validated questions taken from the "Alcohol and other Drug Use" scale of the Youth Risk Behavior Surveillance Survey (CDC surveillance system that monitors adolescent risk behavior) will be administered. Measures include quantity and frequency of use and safety (drinking and driving), Current use of alcohol measured by quantity and frequency of use in the past 30 days (Centers for Disease Control and Prevention, 2018). Scale ranges vary based on questions and questions are scored indivi

Interventions

  • BEHAVIORAL ChangeGradients

Study Locations (1)

California

  • University of California San Francisco Adolescent and Young Adult Medicine Clinic - San Francisco

Trial Details

FieldValue
Enrollment Target 200 participants
Start Date 2024-02-12
Est. Completion 2026-09-30
Phase NA

What NCT04110756 shows while recruiting

NCT04110756 is an interventional study that assigns participants to a tested intervention. The registered 200 participants enrollment target is mid-sized for trials with a published cap, below the 3,491-participant average among 615 other Cancer trials with a reported enrollment target (94% lower).

The record links to 5 conditions, with Cancer appearing as the primary indexed condition, and to 1 intervention - of which ChangeGradients is the first listed.

NCT04110756 reports a single indexed study location in California.

Frequently Asked Questions

What is clinical trial NCT04110756 about?

NCT04110756 is a clinical study titled "ChangeGradients: Promoting Adolescent Health Behavior Change". As most adolescents visit a healthcare provider once a year, health behavior change interventions linked to clinic-based health information technologies hold significant promise for improving healthcare quality and subsequent behavioral health outcomes for adolescents (Baird, 2014, Harris, 2017). Re...

What is the current status of trial NCT04110756?

This trial is currently recruiting. It is a NA study. The enrollment target is 200 participants. The study started on 2024-02-12. Estimated completion is 2026-09-30.

What conditions does trial NCT04110756 study?

This clinical trial studies the following conditions: Cancer, Alcohol Drinking, Adolescent Behavior, Self Efficacy, Risk-Taking.

What interventions are being tested in trial NCT04110756?

The interventions under investigation include: ChangeGradients (BEHAVIORAL).

Who is sponsoring clinical trial NCT04110756?

This trial is sponsored by University of California, San Francisco, which has 1,713 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT04110756 being conducted?

This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Similar trials for Cancer

Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.

Where NCT04110756's enrollment target sits among peer trials

200 231st of 615 higher than 380 of 615 other Cancer trials

participants (enrollment target), bucketed by value

Each bar is a band; taller bars hold more other Cancer trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.

Source ClinicalTrials.gov registry export · 2026-08-08

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Source: ClinicalTrials.gov NCT04110756, the US trial registry maintained by the National Library of Medicine. NCT04110756 (mid enrollment · single site footprint · recruiting) retrieved and formatted by PlainTrial, see methodology.