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NCT04108312 · ClinicalTrials.gov registry record
Age-related Changes in Myeloarchitectonics Across Adulthood in Autism Spectrum Disorder
A clinical trial, sponsored by San Diego State University.
- Completed
- Registry status
- 80
- Enrollment target
NCT04108312 is a clinical trial that has completed, run by San Diego State University. The registered enrollment target is 80 participants.
The verdict
NCT04108312 has completed, sponsored by San Diego State University.
- COMPLETED
- Registry status
- 80 participants
- Enrollment target
Study Summary
There is increasing awareness in the Autism Spectrum Disorder (ASD) research field about the deficit of knowledge with regard to the neurobiological, cognitive, and behavioral changes that occur in adults with ASD across the later portion of the lifespan. Decline in motor skills and cognitive function in typical aging can have devastating impacts on an individual's ability to organize and maintain activities of daily living. While there is an overall lack of research on how these processes unfold across aging specifically in ASD, previous research findings of motor and cognitive deficits in young adults with ASD, localization of these functions to the anterior cerebral cortices, and trajectories of decline in typical aging indicate that motor skills and executive function are particularly at risk in the disorder in later life. In vivo myeloarchitectonic mapping based on Magnetic Resonance Imaging (MRI) provides a unique view of gray matter structure and has the potential to elucidate abnormalities of local cortical connectivity. It has shown promise for the identification of biomarkers of disease pathogenesis in clinical studies, and it provides unique information beyond the cortical thickness measurements that have been employed in previous studies of ASD and typical aging. Myelin mapping may also be a more reliable index of neurobiological aging, given some questions about the accuracy of cortical thickness measurements. Given these properties, it may be a particularly informative measure in the context of potential accelerated decline in ASD. Intracortical myelin development and remodeling are protracted across the typical lifespan, with evidence of abnormal cortical myelination in other neuropsychiatric disorders, as well as in age-related mild cognitive impairment and dementia. In young adults with Autism Spectrum Disorder (ASD) myelin content is reduced in white matter and presumably in cortical gray matter as well. However, patterns of intracortical myelinat
Interventions
- DIAGNOSTIC_TEST Anatomical MRI Scan
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 80 participants |
| Start Date | 2015-05 |
| Est. Completion | 2021-10 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04108312
The ClinicalTrials.gov registry entry for NCT04108312 describes a study currently listed as completed, categorized as an unspecified phase. The registered enrollment target is 80 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is San Diego State University, which has 118 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 1 intervention - of which Anatomical MRI Scan is the first listed.
NCT04108312 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT04108312 about?
NCT04108312 is a clinical study titled "Age-related Changes in Myeloarchitectonics Across Adulthood in Autism Spectrum Disorder". There is increasing awareness in the Autism Spectrum Disorder (ASD) research field about the deficit of knowledge with regard to the neurobiological, cognitive, and behavioral changes that occur in adults with ASD across the later portion of the lifespan. Decline in motor skills and cognitive functi...
What is the current status of trial NCT04108312?
This trial is currently completed. The enrollment target is 80 participants. The study started on 2015-05. Estimated completion is 2021-10.
What interventions are being tested in trial NCT04108312?
The interventions under investigation include: Anatomical MRI Scan (DIAGNOSTIC_TEST).
Who is sponsoring clinical trial NCT04108312?
This trial is sponsored by San Diego State University, which has 118 total clinical trials registered on ClinicalTrials.gov.
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