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NCT04095143 · ClinicalTrials.gov registry record
Ultrasound Markers of Organ Congestion in Severe Acute Kidney Injury
A clinical trial of Acute Kidney Injury and Fluid Overload, sponsored by Centre hospitalier de l'Université de Montréal (CHUM).
- Completed
- Registry status
- 125
- Enrollment target
- 6
- Study locations
NCT04095143: Completed study of Acute Kidney Injury and Fluid Overload, sponsored by Centre hospitalier de l'Université de Montréal (CHUM).
NCT04095143 is a study of Acute Kidney Injury and Fluid Overload that has completed, run by Centre hospitalier de l'Université de Montréal (CHUM). The registered enrollment target is 125 participants, below the 2,329-participant average among 74 other Acute Kidney Injury trials with a reported enrollment target (95% lower). The trial reports 6 study locations across 4 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04095143, a study of Acute Kidney Injury and Fluid Overload, has completed, sponsored by Centre hospitalier de l'Université de Montréal (CHUM).
- COMPLETED
- Registry status
- 125 participants
- Enrollment target
- 6
- Study locations
Study Summary
Fluid overload is associated with adverse outcomes in patients with severe acute kidney injury. It remains unclear if fluid overload is merely a marker of disease severity or if organ congestion is a mediator of complications. Point-of-care ultrasound could be a modality used to assess organ congestion and its clinical implications. The objective of this study is to determine whether ultrasound markers of organ congestion are associated with major adverse kidney events in critically ill patients with severe acute kidney injury.
Primary Outcome
Either death, receipt of renal replacement therapy or sustained loss of kidney function (new onset of estimated glomerular filtration rate (eGFR) \< 60 or, if pre-existing eGFR \< 60, 25% or greater decline in eGFR)
Conditions Studied
Interventions
- DIAGNOSTIC_TEST Portal vein flow
- DIAGNOSTIC_TEST Intra-renal flow
- DIAGNOSTIC_TEST Hepatic vein flow
- DIAGNOSTIC_TEST Pulmonary B-lines
- DIAGNOSTIC_TEST Dimensions of the inferior vena cava
Study Locations (6)
Ontario
- Sunnybrook Health Science Centre - Toronto
- St. Michael's hospital - Toronto
Quebec
- Centre Hospitalier de l'Université de Montréal - Montreal
- Montreal Heart Institute - Montreal
Kentucky
- University of Kentucky - Lexington
Alberta
- University of Alberta - Edmonton
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 125 participants |
| Start Date | 2018-09-04 |
| Est. Completion | 2022-09-01 |
What the finished NCT04095143 record still lists
NCT04095143 is an observational study that tracks outcomes without assigning an intervention. The registered 125 participants enrollment target is mid-sized for trials with a published cap, below the 2,329-participant average among 74 other Acute Kidney Injury trials with a reported enrollment target (95% lower).
The record links to 3 conditions, with Acute Kidney Injury appearing as the primary indexed condition, and to 5 interventions - of which Portal vein flow is the first listed.
NCT04095143 lists 6 locations in 4 states (Ontario, Quebec, Kentucky).
Frequently Asked Questions
What is clinical trial NCT04095143 about?
NCT04095143 is a clinical study titled "Ultrasound Markers of Organ Congestion in Severe Acute Kidney Injury". Fluid overload is associated with adverse outcomes in patients with severe acute kidney injury. It remains unclear if fluid overload is merely a marker of disease severity or if organ congestion is a mediator of complications. Point-of-care ultrasound could be a modality used to assess organ congest...
What is the current status of trial NCT04095143?
This trial is currently completed. The enrollment target is 125 participants. The study started on 2018-09-04. Estimated completion is 2022-09-01.
What conditions does trial NCT04095143 study?
This clinical trial studies the following conditions: Acute Kidney Injury, Fluid Overload, Ultrasonography.
What interventions are being tested in trial NCT04095143?
The interventions under investigation include: Portal vein flow (DIAGNOSTIC_TEST), Intra-renal flow (DIAGNOSTIC_TEST), Hepatic vein flow (DIAGNOSTIC_TEST), Pulmonary B-lines (DIAGNOSTIC_TEST), Dimensions of the inferior vena cava (DIAGNOSTIC_TEST).
Who is sponsoring clinical trial NCT04095143?
This trial is sponsored by Centre hospitalier de l'Université de Montréal (CHUM), which has 10 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04095143 being conducted?
This trial has 6 study locations across Kentucky, Alberta, Ontario, Quebec. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT04095143's enrollment target sits among peer trials
125 40th of 74 higher than 35 of 74 other Acute Kidney Injury trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Acute Kidney Injury trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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