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NCT04061980 · ClinicalTrials.gov registry record · Phase 2
Encorafenib and Binimetinib With or Without Nivolumab in Treating Patients With Metastatic Radioiodine Refractory BRAF V600 Mutant Thyroid Cancer
A Phase 2 study of Metastatic Thyroid Gland Carcinoma and Refractory Thyroid Gland Carcinoma, sponsored by Providence Health & Services.
- Active
- Registry status
- Phase 2
- Development phase
- 24
- Enrollment target
- 1
- Study location
NCT04061980 is a Phase 2 study of Metastatic Thyroid Gland Carcinoma and Refractory Thyroid Gland Carcinoma that is active but no longer recruiting, run by Providence Health & Services. The registered enrollment target is 24 participants, below the 34-participant average among 5 other Metastatic Thyroid Gland Carcinoma trials with a reported enrollment target (29% lower). The trial reports 1 study location across 1 state.
The verdict
NCT04061980, a Phase 2 study of Metastatic Thyroid Gland Carcinoma and Refractory Thyroid Gland Carcinoma, is active but no longer recruiting, sponsored by Providence Health & Services.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 2
- Development phase
- 24 participants
- Enrollment target
- 1
- Study location
Study Summary
This phase II trial studies how well encorafenib and binimetinib given with or without nivolumab works in treating patients with BRAF V600 mutation positive thyroid cancer that has spread to other places in the body (metastatic) and does not respond to radioiodine treatment (refractory). Encorafenib and binimetinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Immunotherapy with monoclonal antibodies, such as nivolumab, may help the body?s immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. The trial aims to find out if the combination of encorafenib and binimetinib, with and without study nivolumab, is a safe and effective way to treat metastatic radioiodine refractory thyroid cancer.
Conditions Studied
Interventions
- BIOLOGICAL Nivolumab
- DRUG Binimetinib
- DRUG Encorafenib
Study Locations (1)
Oregon
- Providence Portland Medical Center - Portland
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 24 participants |
| Start Date | 2020-10-30 |
| Est. Completion | 2027-01-30 |
| Phase | Phase 2 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04061980
The ClinicalTrials.gov registry entry for NCT04061980 describes a study currently listed as active not recruiting, categorized as Phase 2. The registered enrollment target is 24 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 34-participant average among 5 other Metastatic Thyroid Gland Carcinoma trials with a reported enrollment target (29% lower). The listed sponsor is Providence Health & Services, which has 69 total studies on file at ClinicalTrials.gov.
The record links to 7 conditions, with Metastatic Thyroid Gland Carcinoma appearing as the primary indexed condition, and to 3 interventions - of which Nivolumab is the first listed.
NCT04061980 reports 1 study location spanning 1 distinct geographic area - top geographies include Oregon.
Frequently Asked Questions
What is clinical trial NCT04061980 about?
NCT04061980 is a clinical study titled "Encorafenib and Binimetinib With or Without Nivolumab in Treating Patients With Metastatic Radioiodine Refractory BRAF V600 Mutant Thyroid Cancer". This phase II trial studies how well encorafenib and binimetinib given with or without nivolumab works in treating patients with BRAF V600 mutation positive thyroid cancer that has spread to other places in the body (metastatic) and does not respond to radioiodine treatment (refractory). Encorafenib...
What is the current status of trial NCT04061980?
This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 24 participants. The study started on 2020-10-30. Estimated completion is 2027-01-30.
What conditions does trial NCT04061980 study?
This clinical trial studies the following conditions: Metastatic Thyroid Gland Carcinoma, Refractory Thyroid Gland Carcinoma, BRAF V600E Mutation Present, BRAF NP_004324.2:p.V600M, Stage IV Differentiated Thyroid Gland Carcinoma AJCC v8.
What interventions are being tested in trial NCT04061980?
The interventions under investigation include: Nivolumab (BIOLOGICAL), Binimetinib (DRUG), Encorafenib (DRUG).
Who is sponsoring clinical trial NCT04061980?
This trial is sponsored by Providence Health & Services, which has 69 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04061980 being conducted?
This trial has 1 study location across Oregon. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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