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NCT04059250 · ClinicalTrials.gov registry record · NA
Nobio Clinical Study - Demineralization Prevention With a New Antibacterial Restorative Composite
A NA study, sponsored by University of California, San Francisco.
- Completed
- Registry status
- NA
- Development phase
- 25
- Enrollment target
NCT04059250: Completed NA study, sponsored by University of California, San Francisco.
NCT04059250 is a NA study that has completed, run by University of California, San Francisco. The registered enrollment target is 25 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (98% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04059250, a NA study, has completed, sponsored by University of California, San Francisco.
- COMPLETED
- Registry status
- NA
- Development phase
- 25 participants
- Enrollment target
Study Summary
Nobio has developed dental restorative materials with long term antibacterial properties in order to fight recurrent decay/caries around restorations. These composites with incorporated non-leaching antibacterial agents might overcome the vicious circle of newly developed cavities around freshly placed fillings. The investigators will ask lower partial denture wearers to allow them to place a "gap model" with the Nobio-composite and enamel slab in one denture flange. In the other denture flange a gap model with a standard composite will be placed as control. In the laboratory the investigators will test with established methods for demineralization/caries prevention in the test and control enamel slabs, respectively.
Primary Outcome
The mineral loss is determined in the laboratory using cross-sectional microhardness testings of the enamel after the 4-weeks wearing period of the gap-model. The overall relative mineral loss, ΔZ, for each sample is calculated by creating a hardness profile curve by plotting normalized volume percent mineral against distance from the outer enamel surface. The area under the curve that represents ΔZ (µm \* vol % mineral) is calculated using Simpson's integration rule.
Interventions
- DEVICE Nobio composite
- DEVICE traditional composite
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 25 participants |
| Start Date | 2019-05-28 |
| Est. Completion | 2020-03-10 |
| Phase | NA |
What the finished NCT04059250 record still lists
NCT04059250 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 25 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (98% lower).
The record links to 0 conditions, and to 2 interventions - of which Nobio composite is the first listed.
NCT04059250 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04059250 about?
NCT04059250 is a clinical study titled "Nobio Clinical Study - Demineralization Prevention With a New Antibacterial Restorative Composite". Nobio has developed dental restorative materials with long term antibacterial properties in order to fight recurrent decay/caries around restorations. These composites with incorporated non-leaching antibacterial agents might overcome the vicious circle of newly developed cavities around freshly pla...
What is the current status of trial NCT04059250?
This trial is currently completed. It is a NA study. The enrollment target is 25 participants. The study started on 2019-05-28. Estimated completion is 2020-03-10.
What interventions are being tested in trial NCT04059250?
The interventions under investigation include: Nobio composite (DEVICE), traditional composite (DEVICE).
Who is sponsoring clinical trial NCT04059250?
This trial is sponsored by University of California, San Francisco, which has 1,713 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT04059250's enrollment target sits among peer trials
25 1712th of 2000 higher than 265 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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