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NCT04047550 · ClinicalTrials.gov registry record
Respiratory Control and Narcotic Effects
A clinical trial, sponsored by Duke University.
- Completed
- Registry status
- 10
- Enrollment target
NCT04047550: Completed study, sponsored by Duke University.
NCT04047550 is a clinical trial that has completed, run by Duke University. The registered enrollment target is 10 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04047550 has completed, sponsored by Duke University.
- COMPLETED
- Registry status
- 10 participants
- Enrollment target
Study Summary
The aim of this study is to provide data that will assess the role of ventilatory chemosensitivity (respiratory drive) in determining postoperative respiratory depression due to opioids. In a group of patients requiring surgery and admission to hospital, before surgery, ventilatory chemosensitivity will be assessed in the presence or absence of an infusion of remifentanil. Parameters will be correlated with ventilatory depression events after surgery. A secondary aim is to determine whether respiratory depression is more likely during specific phases of sleep.
Primary Outcome
A respiratory event is defined as one or more of the following: 1. Respiratory rate \<60% of baseline 2. Minute ventilation (MV) \<60% of predicted value based on body surface area (BSA). Predicted MV for men=4 x BSA, for women=3.5 x BSA 3. Pulse oximeter reading (SpO2) \<90% (breathing room air) or \<92% (breathing supplemental O2) 4. Transcutaneous PCO2 \>50 mmHg 5. Central or obstructive apnea/hypopnea detected by WatchPAT (Itamar Medical, Atlanta, GA) based on decrease in peripheral arteria
Interventions
- DIAGNOSTIC_TEST Ventilatory chemosensitivity
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 10 participants |
| Start Date | 2018-03-08 |
| Est. Completion | 2019-02-09 |
What the finished NCT04047550 record still lists
NCT04047550 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 10 participants, a relatively small participant target.
The record links to 0 conditions, and to 1 intervention - of which Ventilatory chemosensitivity is the first listed.
NCT04047550 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04047550 about?
NCT04047550 is a clinical study titled "Respiratory Control and Narcotic Effects". The aim of this study is to provide data that will assess the role of ventilatory chemosensitivity (respiratory drive) in determining postoperative respiratory depression due to opioids. In a group of patients requiring surgery and admission to hospital, before surgery, ventilatory chemosensitivity ...
What is the current status of trial NCT04047550?
This trial is currently completed. The enrollment target is 10 participants. The study started on 2018-03-08. Estimated completion is 2019-02-09.
What interventions are being tested in trial NCT04047550?
The interventions under investigation include: Ventilatory chemosensitivity (DIAGNOSTIC_TEST).
Who is sponsoring clinical trial NCT04047550?
This trial is sponsored by Duke University, which has 1,725 total clinical trials registered on ClinicalTrials.gov.
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