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NCT04046991 · ClinicalTrials.gov registry record · Phase 2
Treating Primary Progressive Aphasia (PPA) Using High-definition tDCS
A Phase 2 study, sponsored by University of Pennsylvania.
- Completed
- Registry status
- Phase 2
- Development phase
- 76
- Enrollment target
NCT04046991: Completed Phase 2 study, sponsored by University of Pennsylvania.
NCT04046991 is a Phase 2 study that has completed, run by University of Pennsylvania. The registered enrollment target is 76 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04046991, a Phase 2 study, has completed, sponsored by University of Pennsylvania.
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 76 participants
- Enrollment target
Study Summary
This is a double-blind, sham-controlled, crossover study in which subjects with the non-fluent/agrammatic and logopenic variants of primary progressive aphasia (naPPA and lvPPA, respectively) will undergo language testing and structural and functional brain imaging before and after receiving 10 semi-consecutive daily sessions of real or sham high-definition transcranial direct current stimulation (HD-tDCS) paired with modified constraint-induced language therapy (mCILT). Language testing and brain imaging will be repeated immediately after completion of and 3 months following completion of treatment. The 3-month follow-up will be the primary endpoint. The investigators will examine changes in language performance induced by HD-tDCS + mCILT compared to sham HD-tDCS + mCILT. The investigators will also use network science to analyze brain imaging (fMRI) data to identify network properties associated with baseline PPA severity and tDCS-induced changes in performance. This study will combine knowledge gained from our behavioral, imaging, and network data in order to determine the relative degrees to which these properties predict whether persons with PPA will respond to intervention.
Interventions
- DEVICE high-definition transcranial direct current stimulation
- BEHAVIORAL modified constraint-induced language therapy
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 76 participants |
| Start Date | 2020-08-17 |
| Est. Completion | 2025-06-30 |
| Phase | Phase 2 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04046991
The ClinicalTrials.gov registry entry for NCT04046991 describes a study currently listed as completed, categorized as Phase 2. The registered enrollment target is 76 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University of Pennsylvania, which has 1,423 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 2 interventions - of which high-definition transcranial direct current stimulation is the first listed.
NCT04046991 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT04046991 about?
NCT04046991 is a clinical study titled "Treating Primary Progressive Aphasia (PPA) Using High-definition tDCS". This is a double-blind, sham-controlled, crossover study in which subjects with the non-fluent/agrammatic and logopenic variants of primary progressive aphasia (naPPA and lvPPA, respectively) will undergo language testing and structural and functional brain imaging before and after receiving 10 semi...
What is the current status of trial NCT04046991?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 76 participants. The study started on 2020-08-17. Estimated completion is 2025-06-30.
What interventions are being tested in trial NCT04046991?
The interventions under investigation include: high-definition transcranial direct current stimulation (DEVICE), modified constraint-induced language therapy (BEHAVIORAL).
Who is sponsoring clinical trial NCT04046991?
This trial is sponsored by University of Pennsylvania, which has 1,423 total clinical trials registered on ClinicalTrials.gov.
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