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Dexpramipexole Dose-Ranging Biomarker Study in Subjects With Eosinophilic Asthma
NCT04046939 · View on ClinicalTrials.gov ↗
Study Summary
This is a randomized, double-blind, placebo-controlled, parallel-group, dose-ranging, multi-center study to evaluate the clinical effects of oral administration of dexpramipexole for 12 weeks on peripheral blood eosinophil count in subjects with eosinophilic asthma.
Conditions Studied
Interventions
- DRUG Placebo
- DRUG Dexpramipexole
Study Locations (20)
Florida
- Research Site — Daytona Beach
- Research Site — Miami
- Research Site — Orlando
- Research Site — Tampa
- Research Site — Tampa
California
- Research Site — Los Angeles
- Research Site — Mission Viejo
- Research Site — Westminster
Georgia
- Research Site — Lawrenceville
- Research Site — Winder
Missouri
- Research Site — St Louis
- Research Site — St Louis
New York
- Research Site — Corning
- Research Site — New Hyde Park
Colorado
- Research Site — Denver
Idaho
- Research Site — Boise
Michigan
- Research Site — Farmington Hills
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 534 participants |
| Start Date | 2019-08-15 |
| Est. Completion | 2021-03-02 |
| Phase | Phase 2 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04046939
The ClinicalTrials.gov registry entry for NCT04046939 describes a study currently listed as completed. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 534 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Knopp Biosciences, which has 3 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 2 conditions, with Asthma appearing as the primary indexed condition, and to 2 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT04046939 reports 20 study locations spanning 11 distinct geographic areas — top geographies include Florida, California, Georgia. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT04046939 about?
NCT04046939 is a clinical study titled "Dexpramipexole Dose-Ranging Biomarker Study in Subjects With Eosinophilic Asthma". This is a randomized, double-blind, placebo-controlled, parallel-group, dose-ranging, multi-center study to evaluate the clinical effects of oral administration of dexpramipexole for 12 weeks on peripheral blood eosinophil count in subjects with eosinophilic asthma.
What is the current status of trial NCT04046939?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 534 participants. The study started on 2019-08-15. Estimated completion is 2021-03-02.
What conditions does trial NCT04046939 study?
This clinical trial studies the following conditions: Asthma, Eosinophilic Asthma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT04046939?
The interventions under investigation include: Placebo (DRUG), Dexpramipexole (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT04046939?
This trial is sponsored by Knopp Biosciences, which has 3 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT04046939 being conducted?
This trial has 20 study locations across California, Colorado, Florida, Georgia, Idaho. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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