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NCT04043806 · ClinicalTrials.gov registry record · Phase 3
A Study Evaluating the Long-term Safety of VX-445 Combination Therapy
A Phase 3 study, sponsored by Vertex Pharmaceuticals Incorporated.
- Completed
- Registry status
- Phase 3
- Development phase
- 458
- Enrollment target
NCT04043806: Completed Phase 3 study, sponsored by Vertex Pharmaceuticals Incorporated.
NCT04043806 is a Phase 3 study that has completed, run by Vertex Pharmaceuticals Incorporated. The registered enrollment target is 458 participants, below the 772-participant average among 15,282 other Phase 3 trials with a reported enrollment target (41% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04043806, a Phase 3 study, has completed, sponsored by Vertex Pharmaceuticals Incorporated.
- COMPLETED
- Registry status
- Phase 3
- Development phase
- 458 participants
- Enrollment target
Study Summary
This study evaluated the long-term safety and tolerability of elexacaftor (ELX), tezacaftor (TEZ), and ivacaftor (IVA) triple combination (TC) treatment in participants with cystic fibrosis (CF).
Interventions
- DRUG IVA
- DRUG ELX/TEZ/IVA
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 458 participants |
| Start Date | 2019-08-09 |
| Est. Completion | 2022-12-14 |
| Phase | Phase 3 |
What the finished NCT04043806 record still lists
NCT04043806 is an interventional study that assigns participants to a tested intervention. The registered 458 participants enrollment target is mid-sized for trials with a published cap, below the 772-participant average among 15,282 other Phase 3 trials with a reported enrollment target (41% lower).
The record links to 0 conditions, and to 2 interventions - of which IVA is the first listed.
NCT04043806 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04043806 about?
NCT04043806 is a clinical study titled "A Study Evaluating the Long-term Safety of VX-445 Combination Therapy". This study evaluated the long-term safety and tolerability of elexacaftor (ELX), tezacaftor (TEZ), and ivacaftor (IVA) triple combination (TC) treatment in participants with cystic fibrosis (CF).
What is the current status of trial NCT04043806?
This trial is currently completed. It is a Phase 3 study. The enrollment target is 458 participants. The study started on 2019-08-09. Estimated completion is 2022-12-14.
What interventions are being tested in trial NCT04043806?
The interventions under investigation include: IVA (DRUG), ELX/TEZ/IVA (DRUG).
Who is sponsoring clinical trial NCT04043806?
This trial is sponsored by Vertex Pharmaceuticals Incorporated, which has 191 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT04043806's enrollment target sits among peer trials
458 827th of 2000 higher than 1,174 of 2,000 other Phase 3 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 3 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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