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NCT04021797 · ClinicalTrials.gov registry record · NA
Autonomic Mechanisms of Sleep-dependent Memory Consolidation
A NA study, sponsored by University of California, San Francisco.
- Terminated
- Registry status
- NA
- Development phase
- 12
- Enrollment target
NCT04021797 is a NA study that was terminated before completion, run by University of California, San Francisco. The registered enrollment target is 12 participants.
The verdict
NCT04021797, a NA study, was terminated before completion, sponsored by University of California, San Francisco.
- TERMINATED
- Registry status
- NA
- Development phase
- 12 participants
- Enrollment target
Study Summary
The goal of the proposed project is to identify the impact vagal activity during sleep for memory formation. Nearly 100 years of research contends that sleep plays a critical role in memory consolidation (i.e. the transformation of recent experiences into stable, long-term memories), yet much of this literature has focused on the central nervous system and technologies like electroencephalography (EEG) to unpack neural correlates involved in memory processing. Sleep is also a unique period of autonomic variation and an expansive literature has indicated the critical importance of the autonomic nervous system for memory formation. This project would be amongst the first to examine the autonomic nervous system during sleep as a critical, causal pathway linking sleep to memory processing. The investigators will assess the impact of non-invasive, transcutaneous vagal nerve stimulation on sleep and post-sleep memory performance. Autonomic physiology, including electrocardiography and impedance cardiography, will be gathered at baseline, before the memory task and continuously during sleep to examine vagal tone (i.e. heart rate variability) and sympathetic activation (i.e. pre-ejection period) in response to both active and sham stimulation conditions. Polysomnography will also be gathered during the nap to examine sleep architecture. The proposed research will address a critical gap in the literature by: 1) examining the causal role of the ANS for memory functioning in humans, 2) extending the current understanding of sleep's impact on memory processing, and 3) set the groundwork for novel, sleep-based interventions with the goal of improving cognitive health.
Interventions
- DEVICE transcutaneous vagal nerve stimulation
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 12 participants |
| Start Date | 2019-10-15 |
| Est. Completion | 2020-03-15 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04021797
The ClinicalTrials.gov registry entry for NCT04021797 describes a study currently listed as terminated, categorized as NA. The registered enrollment target is 12 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University of California, San Francisco, which has 1,713 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 1 intervention - of which transcutaneous vagal nerve stimulation is the first listed.
NCT04021797 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT04021797 about?
NCT04021797 is a clinical study titled "Autonomic Mechanisms of Sleep-dependent Memory Consolidation". The goal of the proposed project is to identify the impact vagal activity during sleep for memory formation. Nearly 100 years of research contends that sleep plays a critical role in memory consolidation (i.e. the transformation of recent experiences into stable, long-term memories), yet much of thi...
What is the current status of trial NCT04021797?
This trial is currently terminated. It is a NA study. The enrollment target is 12 participants. The study started on 2019-10-15. Estimated completion is 2020-03-15.
What interventions are being tested in trial NCT04021797?
The interventions under investigation include: transcutaneous vagal nerve stimulation (DEVICE).
Who is sponsoring clinical trial NCT04021797?
This trial is sponsored by University of California, San Francisco, which has 1,713 total clinical trials registered on ClinicalTrials.gov.
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