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NCT04009148 · ClinicalTrials.gov registry record
Cascade Testing in Families With Newly Diagnosed Hereditary Breast and Ovarian Cancer Syndrome
A clinical trial of BRIP1 Gene Mutation and MLH1 Gene Mutation, sponsored by NYU Langone Health.
- Active
- Registry status
- 118
- Enrollment target
- 1
- Study location
NCT04009148 is a study of BRIP1 Gene Mutation and MLH1 Gene Mutation that is active but no longer recruiting, run by NYU Langone Health. The registered enrollment target is 118 participants, below the 1,042-participant average among 3 other BRIP1 Gene Mutation trials with a reported enrollment target (89% lower). The trial reports 1 study location across 1 state.
The verdict
NCT04009148, a study of BRIP1 Gene Mutation and MLH1 Gene Mutation, is active but no longer recruiting, sponsored by NYU Langone Health.
- ACTIVE NOT RECRUITING
- Registry status
- 118 participants
- Enrollment target
- 1
- Study location
Study Summary
Identification of BRCA mutations in ovarian cancer patients may help guide cancer therapies, prognosis, post-operative screening, and other preventative treatments beyond the initial diagnosis. Likewise, genetic testing of ovarian cancer patients for these germline mutations provides invaluable information for families regarding cancer risk, genetic testing, and subsequently indication for risk-reducing surgery. Cascade testing provides a unique opportunity to identify carriers of a deleterious BRCA mutation which can allow for surgical and chemoprevention of prevention of ovarian cancer. There is currently no literature on the rates of referral for the family members.
Conditions Studied
Interventions
- OTHER CASCADE genetic screening
Study Locations (1)
New York
- NYU Langone Health - New York
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 118 participants |
| Start Date | 2019-03-01 |
| Est. Completion | 2027-04-23 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04009148
The ClinicalTrials.gov registry entry for NCT04009148 describes a study currently listed as active not recruiting, categorized as an unspecified phase. The registered enrollment target is 118 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 1,042-participant average among 3 other BRIP1 Gene Mutation trials with a reported enrollment target (89% lower). The listed sponsor is NYU Langone Health, which has 1,164 total studies on file at ClinicalTrials.gov.
The record links to 8 conditions, with BRIP1 Gene Mutation appearing as the primary indexed condition, and to 1 intervention - of which CASCADE genetic screening is the first listed.
NCT04009148 reports 1 study location spanning 1 distinct geographic area - top geographies include New York.
Frequently Asked Questions
What is clinical trial NCT04009148 about?
NCT04009148 is a clinical study titled "Cascade Testing in Families With Newly Diagnosed Hereditary Breast and Ovarian Cancer Syndrome". Identification of BRCA mutations in ovarian cancer patients may help guide cancer therapies, prognosis, post-operative screening, and other preventative treatments beyond the initial diagnosis. Likewise, genetic testing of ovarian cancer patients for these germline mutations provides invaluable info...
What is the current status of trial NCT04009148?
This trial is currently active not recruiting. The enrollment target is 118 participants. The study started on 2019-03-01. Estimated completion is 2027-04-23.
What conditions does trial NCT04009148 study?
This clinical trial studies the following conditions: BRIP1 Gene Mutation, MLH1 Gene Mutation, RAD51C Gene Mutation, BRCA-Mutated Ovarian Carcinoma, MSH2 A636P.
What interventions are being tested in trial NCT04009148?
The interventions under investigation include: CASCADE genetic screening (OTHER).
Who is sponsoring clinical trial NCT04009148?
This trial is sponsored by NYU Langone Health, which has 1,164 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04009148 being conducted?
This trial has 1 study location across New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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