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ACTIVE NOT RECRUITING Phase 1

A Study to Determine the Recommended Dose and Regimen and to Evaluate the Safety and Preliminary Efficacy of CC-92480 in Combination With Standard Treatments in Participants With Relapsed or Refractory Multiple Myeloma (RRMM) and Newly Diagnosed Multiple Myeloma (NDMM)

NCT03989414 · View on ClinicalTrials.gov ↗

Study Summary

The purpose of this study is to evaluate the safety and preliminary efficacy of CC-92480 in combination with standard treatments.

Conditions Studied

Interventions

  • DRUG Dexamethasone
  • DRUG Daratumumab
  • DRUG Carfilzomib
  • DRUG Bortezomib
  • DRUG CC-92480

Study Locations (20)

Massachusetts

  • Local Institution - 117 — Boston
  • Local Institution - 101 — Boston
  • Local Institution - 118 — Boston

Illinois

  • Local Institution - 112 — Chicago
  • Local Institution - 107 — Chicago

Alberta

  • Local Institution - 201 — Calgary
  • Local Institution - 205 — Edmonton

Colorado

  • Local Institution - 119 — Denver

Florida

  • Local Institution - 104 — Tampa

Georgia

  • Local Institution - 108 — Atlanta

Michigan

  • Local Institution - 113 — Detroit

Minnesota

  • Local Institution - 106 — Rochester

Trial Details

FieldValue
Enrollment Target 424 participants
Start Date 2019-09-30
Est. Completion 2026-11-30
Phase Phase 1

Sponsor

Celgene

73 total trials

Interested in This Trial?

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT03989414

The ClinicalTrials.gov registry entry for NCT03989414 describes a study currently listed as active not recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 424 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Celgene, which has 73 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Multiple Myeloma appearing as the primary indexed condition, and to 5 interventions — of which Dexamethasone is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT03989414 reports 20 study locations spanning 16 distinct geographic areas — top geographies include Massachusetts, Illinois, Alberta. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT03989414 about?

NCT03989414 is a clinical study titled "A Study to Determine the Recommended Dose and Regimen and to Evaluate the Safety and Preliminary Efficacy of CC-92480 in Combination With Standard Treatments in Participants With Relapsed or Refractory Multiple Myeloma (RRMM) and Newly Diagnosed Multiple Myeloma (NDMM)". The purpose of this study is to evaluate the safety and preliminary efficacy of CC-92480 in combination with standard treatments.

What is the current status of trial NCT03989414?

This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 424 participants. The study started on 2019-09-30. Estimated completion is 2026-11-30.

What conditions does trial NCT03989414 study?

This clinical trial studies the following conditions: Multiple Myeloma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT03989414?

The interventions under investigation include: Dexamethasone (DRUG), Daratumumab (DRUG), Carfilzomib (DRUG), Bortezomib (DRUG), CC-92480 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT03989414?

This trial is sponsored by Celgene, which has 73 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT03989414 being conducted?

This trial has 20 study locations across Colorado, Florida, Georgia, Illinois, Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial