Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
Assessing an Oral EGFR Inhibitor, Sunvozertinib in Patients Who Have Advanced Non-small Cell Lung Cancer With EGFR or HER2 Mutation (WU-KONG1)
NCT03974022 · View on ClinicalTrials.gov ↗
Study Summary
This study will treat patients with advanced NSCLC with EGFR or HER2 mutation who have progressed following prior therapy. This is the first time this drug is tested in patients, and so it will help to understand what type of side effects may occur with the drug treatment. It will also measure the levels of drug in the body and preliminarily assess its anti-cancer activity as monotherapy.
Conditions Studied
Interventions
- DRUG Sunvozertinib
Study Locations (20)
Other
- Fundacion Respirar - Consultorios Medicos Dr. Doreski — Cabildo
- CEMIC Centro de Educación Médica e Investigaciones Clínicas - Hospital Universitario sede Saavedra — Ciudad Autónoma Buenos Aires
- Centro Medico Austral OMI — Ciudad Autónoma Buenos Aires
- Diabaid — Ciudad Autónoma Buenos Aires
- Fundacion CENIT Para La Investigacion en Neurociencias — Ciudad Autónoma Buenos Aires
- Instituto Argentino de Diagnositco y Tratamiento S.A. — Ciudad Autónoma Buenos Aires
- Instituto Medico de la Fundacion de Estudios Clínicos — Ciudad Autónoma Buenos Aires
- Centro de Investigación Pergamino SA — Pergamino
California
- University of California, San Diego (UCSD) - Moores Cancer Center — La Jolla
- University of California Irvine Medical Center (UCIMC) - Chao Family Comprehensive Cancer Center — Orange
- Innovative Clinical Research Institute, LLC — Whittier
New York
- Northwell Health - Centers for Advanced Medicine — New Hyde Park
- Laura and Isaac Perlmutter Cancer Center — New York
- Icahn School of Medicine at Mount Sinai — New York
Colorado
- University of Colorado Hospital - Anschutz Cancer Pavilion — Aurora
Florida
- H. Lee Moffitt Cancer Center & Research Institute — Tampa
Massachusetts
- Dana-Farber Cancer Institute — Boston
Michigan
- Michigan Center of Medical Research — Farmington Hills
Ohio
- The Ohio State University Comprehensive Cancer Center — Columbus
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 315 participants |
| Start Date | 2019-07-09 |
| Est. Completion | 2026-12 |
| Phase | Phase 1 |
Interested in This Trial?
Always speak with your doctor before enrolling in a clinical trial.
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT03974022
The ClinicalTrials.gov registry entry for NCT03974022 describes a study currently listed as active not recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 315 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Dizal Pharmaceuticals, which has 7 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Non-Small Cell Lung Cancer appearing as the primary indexed condition, and to 1 intervention — of which Sunvozertinib is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT03974022 reports 20 study locations spanning 9 distinct geographic areas — top geographies include Other, California, New York. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT03974022 about?
NCT03974022 is a clinical study titled "Assessing an Oral EGFR Inhibitor, Sunvozertinib in Patients Who Have Advanced Non-small Cell Lung Cancer With EGFR or HER2 Mutation (WU-KONG1)". This study will treat patients with advanced NSCLC with EGFR or HER2 mutation who have progressed following prior therapy. This is the first time this drug is tested in patients, and so it will help to understand what type of side effects may occur with the drug treatment. It will also measure the l...
What is the current status of trial NCT03974022?
This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 315 participants. The study started on 2019-07-09. Estimated completion is 2026-12.
What conditions does trial NCT03974022 study?
This clinical trial studies the following conditions: Non-Small Cell Lung Cancer. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT03974022?
The interventions under investigation include: Sunvozertinib (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT03974022?
This trial is sponsored by Dizal Pharmaceuticals, which has 7 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT03974022 being conducted?
This trial has 20 study locations across California, Colorado, Florida, Massachusetts, Michigan. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
How Clinical Trials Work
Understand phases 1-4, trial design, randomization, and the informed consent process.
Patient Rights in Clinical Trials
Your rights as a participant: consent, withdrawal, privacy, and who to contact.
Finding the Right Clinical Trial
A practical guide to searching trials, understanding eligibility, and evaluating options.
All Guides
Browse our complete library of clinical trial educational resources.
Read our methodology — how this data is sourced, computed, and verified.