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NCT03970616 · ClinicalTrials.gov registry record · Phase 1
A Study of Tivozanib in Combination With Durvalumab in Subjects With Advanced Hepatocellular Carcinoma
A Phase 1 study, sponsored by AVEO Pharmaceuticals.
- Terminated
- Registry status
- Phase 1
- Development phase
- 27
- Enrollment target
NCT03970616: Clinical Trial Phase 1 study, sponsored by AVEO Pharmaceuticals.
NCT03970616 is a Phase 1 study that was terminated before completion, run by AVEO Pharmaceuticals. The registered enrollment target is 27 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (55% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03970616, a Phase 1 study, was terminated before completion, sponsored by AVEO Pharmaceuticals.
- TERMINATED
- Registry status
- Phase 1
- Development phase
- 27 participants
- Enrollment target
Study Summary
This study will evaluate the safety, tolerability, DLTs, MTD, and preliminary anti tumor activity of tivozanib in combination with durvalumab in subjects with advanced HCC.
Primary Outcome
To establish the safety of tivozanib in combination with durvalumab in subjects with untreated advanced hepatocellular carcinoma (HCC).
Interventions
- DRUG Durvalumab
- DRUG Tivozanib
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 27 participants |
| Start Date | 2019-09-30 |
| Est. Completion | 2023-04-04 |
| Phase | Phase 1 |
Why NCT03970616 stopped before completion
NCT03970616 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 27 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (55% lower).
The record links to 0 conditions, and to 2 interventions - of which Durvalumab is the first listed.
NCT03970616 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03970616 about?
NCT03970616 is a clinical study titled "A Study of Tivozanib in Combination With Durvalumab in Subjects With Advanced Hepatocellular Carcinoma". This study will evaluate the safety, tolerability, DLTs, MTD, and preliminary anti tumor activity of tivozanib in combination with durvalumab in subjects with advanced HCC.
What is the current status of trial NCT03970616?
This trial is currently terminated. It is a Phase 1 study. The enrollment target is 27 participants. The study started on 2019-09-30. Estimated completion is 2023-04-04.
What interventions are being tested in trial NCT03970616?
The interventions under investigation include: Durvalumab (DRUG), Tivozanib (DRUG).
Who is sponsoring clinical trial NCT03970616?
This trial is sponsored by AVEO Pharmaceuticals, which has 27 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT03970616's enrollment target sits among peer trials
27 1463rd of 2000 higher than 519 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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