Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

NCT03959176 · ClinicalTrials.gov registry record · Phase 4

The Effect of Brimonidine

A Phase 4 study, sponsored by Wake Forest University Health Sciences.

Completed
Registry status
Phase 4
Development phase
13
Enrollment target

NCT03959176: Completed Phase 4 study, sponsored by Wake Forest University Health Sciences.

NCT03959176 is a Phase 4 study that has completed, run by Wake Forest University Health Sciences. The registered enrollment target is 13 participants, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (97% lower). According to ClinicalTrials.gov, the official US trial registry.

View on ClinicalTrials.gov ↗

View your shortlist →

The verdict

NCT03959176, a Phase 4 study, has completed, sponsored by Wake Forest University Health Sciences.

COMPLETED
Registry status
Phase 4
Development phase
13 participants
Enrollment target

Study Summary

This study will evaluate whether pre-treating patients with Brimonidine 0.2% before and/or after dilating the pupils will help to control the changes in intraocular pressure often seen when using dilating drops. The study will also evaluate the effects of different sequences of administering dilating drops along with Brimonidine on pupil size and reactivity.

Primary Outcome

To observe how differing the sequence of administration of Tropicamide 1%/Phenylephrine 2.5% and Brimonidine 0.2% influences intraocular pressure.

Interventions

  • DRUG Brimonidine
  • DRUG Tropicamide
  • DRUG Phenylephrine Ophthalmic Product

Trial Details

FieldValue
Enrollment Target 13 participants
Start Date 2019-07-20
Est. Completion 2019-07-20
Phase Phase 4
Wake Forest University Health Sciences

1,140 total trials

What the finished NCT03959176 record still lists

NCT03959176 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 13 participants, a relatively small participant target, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (97% lower).

The record links to 0 conditions, and to 3 interventions - of which Brimonidine is the first listed.

NCT03959176 does not publish any study locations in the registry export this page uses.

Frequently Asked Questions

What is clinical trial NCT03959176 about?

NCT03959176 is a clinical study titled "The Effect of Brimonidine". This study will evaluate whether pre-treating patients with Brimonidine 0.2% before and/or after dilating the pupils will help to control the changes in intraocular pressure often seen when using dilating drops. The study will also evaluate the effects of different sequences of administering dilatin...

What is the current status of trial NCT03959176?

This trial is currently completed. It is a Phase 4 study. The enrollment target is 13 participants. The study started on 2019-07-20. Estimated completion is 2019-07-20.

What interventions are being tested in trial NCT03959176?

The interventions under investigation include: Brimonidine (DRUG), Tropicamide (DRUG), Phenylephrine Ophthalmic Product (DRUG).

Who is sponsoring clinical trial NCT03959176?

This trial is sponsored by Wake Forest University Health Sciences, which has 1,140 total clinical trials registered on ClinicalTrials.gov.

How this trial's enrollment target compares

Where NCT03959176's enrollment target sits among peer trials

13 1910th of 2000 higher than 88 of 2,000 other Phase 4 trials

participants (enrollment target), bucketed by value

Each bar is a band; taller bars hold more other Phase 4 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.

Source ClinicalTrials.gov registry export · 2026-08-08

Nationwide trials with similar profiles

Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.

Similar enrollment target

  • NCT03125655 · 13 participants

    Regulation of Inflammatory Genes in Psoriasis

  • NCT03774446 · 13 participants · Phase 2

    Multicenter Study of Seliciclib (R-roscovitine) for Cushing Disease

  • NCT03830151 · 13 participants · Phase 1

    Hyperpolarized Carbon C 13 Pyruvate in Diagnosing Glioma in Patients With Brain Tumors

  • NCT04573231 · 13 participants · Phase 2

    Evaluation of PSMA in HER2- AR+ Metastatic Breast Cancer

Similar registry start date

  • NCT05962346 · started 2026-12 · NA

    Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia

  • NCT07125183 · started 2026-12 · Phase 2

    Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma

  • NCT07292298 · started 2026-11 · Phase 2

    Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates

  • NCT04263285 · started 2026-10 · NA

    Treatment of Depression Post-SCI

Source: ClinicalTrials.gov NCT03959176, the US trial registry maintained by the National Library of Medicine. NCT03959176 (small enrollment · none site footprint · completed) retrieved and formatted by PlainTrial, see methodology.