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NCT03958474 · ClinicalTrials.gov registry record · Early Phase 1
Neurobehavioral Mechanisms of Choice in Opioid Use Disorder
A Early Phase 1 study, sponsored by Joshua A. Lile, Ph.D..
- Completed
- Registry status
- Early Phase 1
- Development phase
- 12
- Enrollment target
NCT03958474: Completed Early Phase 1 study, sponsored by Joshua A. Lile, Ph.D..
NCT03958474 is a Early Phase 1 study that has completed, run by Joshua A. Lile, Ph.D.. The registered enrollment target is 12 participants, below the 53-participant average among 2,764 other Early Phase 1 trials with a reported enrollment target (77% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03958474, a Early Phase 1 study, has completed, sponsored by Joshua A. Lile, Ph.D..
- COMPLETED
- Registry status
- Early Phase 1
- Development phase
- 12 participants
- Enrollment target
Study Summary
The objective of this protocol is to use probabilistic reinforcement learning choice tasks and magnetic resonance neuroimaging to demonstrate the impact of problematic opioid use and opioid withdrawal on dynamic decision-making and reveal the neurobehavioral and neurobiological processes underlying abnormal task performance. A second objective is to identify an appropriate dose of intravenous remifentanil for subsequent studies in physically dependent individuals with opioid use disorder.
Primary Outcome
Subjects completed a 300-trial probabilistic concurrent monetary choice task, also known as an n-bandit task (here, n=2 choice options, with unsigned probability reversals every 50 trials). In each trial, subjects chose between two options signaled by blue and green envelopes. When a reward was scheduled for the chosen option, subjects were notified they earned $0.25 USD; task earnings were provided upon session completion. Choice of the high probability option was more likely to be reinforced t
Interventions
- DRUG Oxycodone
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 12 participants |
| Start Date | 2019-08-16 |
| Est. Completion | 2025-07-10 |
| Phase | Early Phase 1 |
What the finished NCT03958474 record still lists
NCT03958474 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 12 participants, a relatively small participant target, below the 53-participant average among 2,764 other Early Phase 1 trials with a reported enrollment target (77% lower).
The record links to 0 conditions, and to 1 intervention - of which Oxycodone is the first listed.
NCT03958474 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03958474 about?
NCT03958474 is a clinical study titled "Neurobehavioral Mechanisms of Choice in Opioid Use Disorder". The objective of this protocol is to use probabilistic reinforcement learning choice tasks and magnetic resonance neuroimaging to demonstrate the impact of problematic opioid use and opioid withdrawal on dynamic decision-making and reveal the neurobehavioral and neurobiological processes underlying ...
What is the current status of trial NCT03958474?
This trial is currently completed. It is a Early Phase 1 study. The enrollment target is 12 participants. The study started on 2019-08-16. Estimated completion is 2025-07-10.
What interventions are being tested in trial NCT03958474?
The interventions under investigation include: Oxycodone (DRUG).
Who is sponsoring clinical trial NCT03958474?
This trial is sponsored by Joshua A. Lile, Ph.D., which has 7 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT03958474's enrollment target sits among peer trials
12 1530th of 2000 higher than 401 of 2,000 other Early Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Early Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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