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NCT03957213 · ClinicalTrials.gov registry record · NA
Enhancing Cognition in Older Adults With Intermittent Hypoxia and Cognitive Training
A NA study, sponsored by University of Florida.
- Completed
- Registry status
- NA
- Development phase
- 11
- Enrollment target
NCT03957213: Completed NA study, sponsored by University of Florida.
NCT03957213 is a NA study that has completed, run by University of Florida. The registered enrollment target is 11 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03957213, a NA study, has completed, sponsored by University of Florida.
- COMPLETED
- Registry status
- NA
- Development phase
- 11 participants
- Enrollment target
Study Summary
The current study will investigate methods for enhancing cognitive training (CT) effects in healthy older adults by employing a combination of interventions facilitating neural plasticity and optimizing readiness for learning. Adults over the age of 65 represent the fastest growing group in the US population. As such, age-related cognitive decline represents a major concern for public health. Recent research suggests that cognitive training in older adults can improve cognitive performance, with effects lasting up to 10 years. However, these effects are typically limited to the tasks trained, with little transfer to other cognitive abilities or everyday skills. A pilot randomized clinical trial will examine the individual and combined impact of pairing cognitive training with an intermittent hypoxia (IH) intervention. The investigators will compare changes in cognitive and brain function resulting from CT combined with active IH versus CT combined with sham IH using a comprehensive neurocognitive, clinical, and multimodal neuroimaging assessment of brain structure, function, and metabolic state. Functional magnetic resonance imaging (FMRI) will be used to assess brain response during speed of processing; the active cognitive abilities trained by CT. Magnetic resonance spectroscopy (MRS) will assess cerebral metabolites, including ATP and GABA concentrations sensitive to neural plasticity.
Primary Outcome
Determine whether training performance improves when cognitive training (CT) is coupled with intermittent hypoxia (IH). Posit Science Double Decision is designed to improve the speed and accuracy with which the brain can process visual information, both at the center of gaze and on the periphery, known as "useful field of view" (UFOV). Scored in milliseconds, where lower scores indicate better processing speeds. CT will involve up to 10 hours of training over 2-weeks (10 days) and employs a Posi
Interventions
- DEVICE Acute Intermittent Hypoxia
- BEHAVIORAL Computerized Cognitive Training
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 11 participants |
| Start Date | 2019-06-01 |
| Est. Completion | 2021-11-22 |
| Phase | NA |
What the finished NCT03957213 record still lists
NCT03957213 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 11 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower).
The record links to 0 conditions, and to 2 interventions - of which Acute Intermittent Hypoxia is the first listed.
NCT03957213 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03957213 about?
NCT03957213 is a clinical study titled "Enhancing Cognition in Older Adults With Intermittent Hypoxia and Cognitive Training". The current study will investigate methods for enhancing cognitive training (CT) effects in healthy older adults by employing a combination of interventions facilitating neural plasticity and optimizing readiness for learning. Adults over the age of 65 represent the fastest growing group in the US p...
What is the current status of trial NCT03957213?
This trial is currently completed. It is a NA study. The enrollment target is 11 participants. The study started on 2019-06-01. Estimated completion is 2021-11-22.
What interventions are being tested in trial NCT03957213?
The interventions under investigation include: Acute Intermittent Hypoxia (DEVICE), Computerized Cognitive Training (BEHAVIORAL).
Who is sponsoring clinical trial NCT03957213?
This trial is sponsored by University of Florida, which has 1,106 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT03957213's enrollment target sits among peer trials
11 1927th of 2000 higher than 74 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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