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NCT03953300 · ClinicalTrials.gov registry record · Phase 4
Benralizumab Airway Remodeling Study in Severe Eosinophilic Asthmatics
A Phase 4 study of Asthma, sponsored by AstraZeneca.
- Active
- Registry status
- Phase 4
- Development phase
- 75
- Enrollment target
- 20
- Study locations
NCT03953300: Active Phase 4 study of Asthma, sponsored by AstraZeneca.
NCT03953300 is a Phase 4 study of Asthma that is active but no longer recruiting, run by AstraZeneca. The registered enrollment target is 75 participants, below the 1,563-participant average among 374 other Asthma trials with a reported enrollment target (95% lower). The trial reports 20 study locations across 15 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03953300, a Phase 4 study of Asthma, is active but no longer recruiting, sponsored by AstraZeneca.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 4
- Development phase
- 75 participants
- Enrollment target
- 20
- Study locations
Study Summary
The purpose of the study is to evaluate effect of benralizumab on structural and lung function changes in severe eosinophilic asthmatics. Changes will be assessed over 48 week treatment period in patients with persistent symptoms despite standard therapy of inhaled corticosteroids (ICS) plus long acting B2-agonist (LABA) with or without additional controller medication. Patients who complete treatment will enter 4 weeks follow-up period.
Primary Outcome
The change in eosinophil numbers expressed as number/mm2 in submucosa as measured by major basic protein (MBP) staining in endobronchial biopsies
Conditions Studied
Interventions
- BIOLOGICAL Placebo
- BIOLOGICAL Benralizumab
Study Locations (20)
Texas
- Research Site - Galveston
- Research Site - Lewisville
- Research Site - Mansfield
Florida
- Research Site - Jacksonville
- Research Site - Miami
Michigan
- Research Site - Ann Arbor
- Research Site - Bloomfield Hills
North Carolina
- Research Site - New Bern
- Research Site - Winston-Salem
Alabama
- Research Site - Birmingham
California
- Research Site - Los Angeles
Georgia
- Research Site - Snellville
Indiana
- Research Site - Indianapolis
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 75 participants |
| Start Date | 2019-10-08 |
| Est. Completion | 2026-10-19 |
| Phase | Phase 4 |
What the registry record for NCT03953300 still lists
NCT03953300 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 75 participants, a relatively small participant target, below the 1,563-participant average among 374 other Asthma trials with a reported enrollment target (95% lower).
The record links to 1 condition, with Asthma appearing as the primary indexed condition, and to 2 interventions - of which Placebo is the first listed.
NCT03953300 names 20 study sites across 15 states, led by Texas, Florida, Michigan.
Frequently Asked Questions
What is clinical trial NCT03953300 about?
NCT03953300 is a clinical study titled "Benralizumab Airway Remodeling Study in Severe Eosinophilic Asthmatics". The purpose of the study is to evaluate effect of benralizumab on structural and lung function changes in severe eosinophilic asthmatics. Changes will be assessed over 48 week treatment period in patients with persistent symptoms despite standard therapy of inhaled corticosteroids (ICS) plus long a...
What is the current status of trial NCT03953300?
This trial is currently active not recruiting. It is a Phase 4 study. The enrollment target is 75 participants. The study started on 2019-10-08. Estimated completion is 2026-10-19.
What conditions does trial NCT03953300 study?
This clinical trial studies the following conditions: Asthma.
What interventions are being tested in trial NCT03953300?
The interventions under investigation include: Placebo (BIOLOGICAL), Benralizumab (BIOLOGICAL).
Who is sponsoring clinical trial NCT03953300?
This trial is sponsored by AstraZeneca, which has 1,285 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT03953300 being conducted?
This trial has 20 study locations across Alabama, California, Florida, Georgia, Indiana. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Asthma
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT03953300's enrollment target sits among peer trials
75 230th of 374 higher than 140 of 374 other Asthma trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Asthma trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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