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RECRUITING Phase 2

Androgen Deprivation Therapy (ADT) and Pembrolizumab for Advanced Stage Androgen Receptor-positive Salivary Gland Carcinoma

NCT03942653 · View on ClinicalTrials.gov ↗

Study Summary

A Phase II, multi-center, single-arm, non-blinded study combining androgen deprivation therapy (ADT) and pembrolizumab for patients with metastatic or locally recurrent androgen receptor-positive salivary gland carcinoma, not amenable to surgery or radiation.

Conditions Studied

Interventions

  • DRUG Pembrolizumab
  • DRUG Goserelin Acetate

Study Locations (7)

Illinois

  • Northwestern University Feinberg School of Medicine — Chicago
  • University of Illinois Cancer Center — Chicago

Iowa

  • University of Iowa Hospitals and Clinics — Iowa City

Maryland

  • Univeristy of Maryland — Baltimore

Michigan

  • University of Michigan Health System — Ann Arbor

Minnesota

  • University of Minnesota: Masonic Cancer Center — Minneapolis

Wisconsin

  • University of Wisconsin — Madison

Trial Details

FieldValue
Enrollment Target 20 participants
Start Date 2019-05-30
Est. Completion 2026-08
Phase Phase 2

Sponsor

Manish Patel

1 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT03942653

The ClinicalTrials.gov registry entry for NCT03942653 describes a study currently listed as recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 20 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Manish Patel, which has 1 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Salivary Gland Carcinoma appearing as the primary indexed condition, and to 2 interventions — of which Pembrolizumab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT03942653 reports 7 study locations spanning 6 distinct geographic areas — top geographies include Illinois, Iowa, Maryland. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT03942653 about?

NCT03942653 is a clinical study titled "Androgen Deprivation Therapy (ADT) and Pembrolizumab for Advanced Stage Androgen Receptor-positive Salivary Gland Carcinoma". A Phase II, multi-center, single-arm, non-blinded study combining androgen deprivation therapy (ADT) and pembrolizumab for patients with metastatic or locally recurrent androgen receptor-positive salivary gland carcinoma, not amenable to surgery or radiation.

What is the current status of trial NCT03942653?

This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 20 participants. The study started on 2019-05-30. Estimated completion is 2026-08.

What conditions does trial NCT03942653 study?

This clinical trial studies the following conditions: Salivary Gland Carcinoma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT03942653?

The interventions under investigation include: Pembrolizumab (DRUG), Goserelin Acetate (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT03942653?

This trial is sponsored by Manish Patel, which has 1 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT03942653 being conducted?

This trial has 7 study locations across Illinois, Iowa, Maryland, Michigan, Minnesota. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial