Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT03934424 · ClinicalTrials.gov registry record · NA
Weight Stigma Effect on Neural Control of Appetite
A NA study of Appetitive Behavior, sponsored by University of Missouri-Columbia.
- Completed
- Registry status
- NA
- Development phase
- 40
- Enrollment target
- 1
- Study location
NCT03934424: Completed NA study of Appetitive Behavior, sponsored by University of Missouri-Columbia.
NCT03934424 is a NA study of Appetitive Behavior that has completed, run by University of Missouri-Columbia. The registered enrollment target is 40 participants, below the 54-participant average among 11 other Appetitive Behavior trials with a reported enrollment target (26% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03934424, a NA study of Appetitive Behavior, has completed, sponsored by University of Missouri-Columbia.
- COMPLETED
- Registry status
- NA
- Development phase
- 40 participants
- Enrollment target
- 1
- Study location
Study Summary
The limited data available suggest that exposure to weight-based stigmatization leads to overeating and increased desire for food. In the present study, overweight and obese individuals (BMI from 25-35 kg/m2) who are generally healthy will be randomized to read a weight-stigma article or control article and subsequently scanned to collect fMRI data. These procedures will be employed to accomplish two specific aims. Specific Aim 1: Determine the neural mechanisms involved in exposure to weight stigma on central control of appetite in overweight and obese individuals. To accomplish this aim we will collect fMRI data in study participants when viewing food and scenery pictures after being exposed to either a weight-stigma or control article. In addition, participants will complete validated questionnaires to measure perceived weight-stigma experiences and social support for eating and physical activity. Hypothesis: After reading an article depicting weight stigmatization, when shown pictures of food in the fMRI scanner, overweight/obese individuals that perceive themselves as having experienced higher levels of weight stigma and lower levels of social support, will have higher activations of brain regions that control appetite and food reward (amygdala, orbitofrontal cortex, striatum, insula) and reduced activations in brain areas that regulate self-control and decision making (prefrontal cortex and cingulate cortex respectively) compared to a control group that reads a non-weight stigma article. Specific Aim 2: To assess the relationship between activity in appetitive and self-control brain regions and self-reported, eating-related behavior. To accomplish this aim, participants will also complete questionnaires that measure self-reported food intake motivation (dietary restraint, disinhibition and hunger), appetitive responses, and mood. Hypothesis: Higher activations in appetite and reward regions and lower activations in self-control brain regions will be correlat
Primary Outcome
BOLD contrast-Measures activity in the brain by detecting changes in cerebral blood flow
Conditions Studied
Interventions
- BEHAVIORAL Weight stigma
- BEHAVIORAL Ethnic stigma
Study Locations (1)
Missouri
- University of Missouri-Columbia - Columbia
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 40 participants |
| Start Date | 2019-04-10 |
| Est. Completion | 2019-07-25 |
| Phase | NA |
What the finished NCT03934424 record still lists
NCT03934424 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 40 participants, a relatively small participant target, below the 54-participant average among 11 other Appetitive Behavior trials with a reported enrollment target (26% lower).
The record links to 1 condition, with Appetitive Behavior appearing as the primary indexed condition, and to 2 interventions - of which Weight stigma is the first listed.
NCT03934424 reports a single indexed study location in Missouri.
Frequently Asked Questions
What is clinical trial NCT03934424 about?
NCT03934424 is a clinical study titled "Weight Stigma Effect on Neural Control of Appetite". The limited data available suggest that exposure to weight-based stigmatization leads to overeating and increased desire for food. In the present study, overweight and obese individuals (BMI from 25-35 kg/m2) who are generally healthy will be randomized to read a weight-stigma article or control art...
What is the current status of trial NCT03934424?
This trial is currently completed. It is a NA study. The enrollment target is 40 participants. The study started on 2019-04-10. Estimated completion is 2019-07-25.
What conditions does trial NCT03934424 study?
This clinical trial studies the following conditions: Appetitive Behavior.
What interventions are being tested in trial NCT03934424?
The interventions under investigation include: Weight stigma (BEHAVIORAL), Ethnic stigma (BEHAVIORAL).
Who is sponsoring clinical trial NCT03934424?
This trial is sponsored by University of Missouri-Columbia, which has 291 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT03934424 being conducted?
This trial has 1 study location across Missouri. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Appetitive Behavior
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT03934424's enrollment target sits among peer trials
40 4th of 11 higher than 7 of 11 other Appetitive Behavior trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Appetitive Behavior trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
Food for Thought: Executive Functioning Around Eating Among Children
RECRUITING · NA
-
Validation of a Novel Cerebellar-striatal Satiety Circuit in Humans
RECRUITING · NA
-
Exercise, Brain Activity, and Weight Maintenance
RECRUITING · NA
-
SATISFY (geleSis100 Effects on AppeTIte Sensations, Feeding Behavior and Dietary energY)
COMPLETED · NA
-
Whole Grains, Gastric Emptying and Glycemic Response
COMPLETED · NA
-
Barley Beta-glucan, Glycemic Control, and Appetite
COMPLETED · NA
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT01306019 · 40 participants · Phase 1
Lentiviral Gene Transfer for Treatment of Children Older Than Two Years of Age With X-Linked Severe Combined Immunodeficiency (XSCID)
- NCT01608152 · 40 participants
Development of a Video Game for the Improvement of Outcomes in Stem Cell Transplant Survivors
- NCT01668082 · 40 participants · NA
An Investigation of Brain Tumor Metabolism in Patients Undergoing Surgical Resection
- NCT02015013 · 40 participants · Phase 2
Hematopoietic Stem Cell Mobilization in Idiopathic CD4 Lymphocytopenia Patients and Healthy Controls for the Study of T Cell Maturation and Trafficking in Murine Models
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI