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NCT03892772 · ClinicalTrials.gov registry record · Phase 1
Combination Pharmacological Interventions for Multiple Mechanisms of Obstructive Sleep Apnea
A Phase 1 study, sponsored by Brigham and Women's Hospital.
- Completed
- Registry status
- Phase 1
- Development phase
- 23
- Enrollment target
NCT03892772: Completed Phase 1 study, sponsored by Brigham and Women's Hospital.
NCT03892772 is a Phase 1 study that has completed, run by Brigham and Women's Hospital. The registered enrollment target is 23 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (62% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03892772, a Phase 1 study, has completed, sponsored by Brigham and Women's Hospital.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 23 participants
- Enrollment target
Study Summary
Currently, there is no pharmacological intervention for OSA that targets multiple pathophysiological deficits in combination. Here the investigators study the effect on sleep apnea severity of combinations of pharmacological agents that stimulate the pharyngeal muscles, stabilize ventilatory control, and increase the arousal threshold.
Primary Outcome
Apneas and hypopneas per hour (3% desat and/or arousal), % change from baseline
Interventions
- DRUG placebo
- DRUG SAS0421a
- DRUG SAS0421b
- DRUG SAS0421c
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 23 participants |
| Start Date | 2019-01-14 |
| Est. Completion | 2021-07-03 |
| Phase | Phase 1 |
What the finished NCT03892772 record still lists
NCT03892772 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 23 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (62% lower).
The record links to 0 conditions, and to 4 interventions - of which placebo is the first listed.
NCT03892772 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03892772 about?
NCT03892772 is a clinical study titled "Combination Pharmacological Interventions for Multiple Mechanisms of Obstructive Sleep Apnea". Currently, there is no pharmacological intervention for OSA that targets multiple pathophysiological deficits in combination. Here the investigators study the effect on sleep apnea severity of combinations of pharmacological agents that stimulate the pharyngeal muscles, stabilize ventilatory control...
What is the current status of trial NCT03892772?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 23 participants. The study started on 2019-01-14. Estimated completion is 2021-07-03.
What interventions are being tested in trial NCT03892772?
The interventions under investigation include: placebo (DRUG), SAS0421a (DRUG), SAS0421b (DRUG), SAS0421c (DRUG).
Who is sponsoring clinical trial NCT03892772?
This trial is sponsored by Brigham and Women's Hospital, which has 937 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT03892772's enrollment target sits among peer trials
23 1596th of 2000 higher than 400 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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