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NCT03867344 · ClinicalTrials.gov registry record · NA
The Functional Neuroanatomy of the Human Physiological Stress Response
A NA study, sponsored by Brigham and Women's Hospital.
- Completed
- Registry status
- NA
- Development phase
- 74
- Enrollment target
NCT03867344: Completed NA study, sponsored by Brigham and Women's Hospital.
NCT03867344 is a NA study that has completed, run by Brigham and Women's Hospital. The registered enrollment target is 74 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (95% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03867344, a NA study, has completed, sponsored by Brigham and Women's Hospital.
- COMPLETED
- Registry status
- NA
- Development phase
- 74 participants
- Enrollment target
Study Summary
The purpose of this study is to examine the effect of a moderately low blood sugar stress on the nervous system. The investigators hope that information obtained from completing this study will help to reveal information about how a non-psychological stress impacts the parts of the brain that react to stress and the autonomic nervous system. The autonomic nervous system is the part of the nervous system that provides the body with involuntary or automatic control of heart rate, blood pressure, and breathing.
Primary Outcome
Functional MRI will be performed following physiological stress (hypoglycemia) or placebo (normoglycemia) and a functional connectivity analysis will be performed on the fMRI data. The outcome will be alterations in neural network connectivity, as measured by changes in Pearson-correlation coefficients among the following brain structures: right anterior insula and anterior cingulate cortex; right anterior insula and hypothalamus; hypothalamus and anterior cingulate cortex; hypothalamus and amyg
Interventions
- OTHER Hypoglycemic Hyperinsulinemic Clamp
- OTHER Normoglycemic Hyperinsulinemic Clamp
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 74 participants |
| Start Date | 2019-10-01 |
| Est. Completion | 2025-12-30 |
| Phase | NA |
What the finished NCT03867344 record still lists
NCT03867344 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 74 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (95% lower).
The record links to 0 conditions, and to 2 interventions - of which Hypoglycemic Hyperinsulinemic Clamp is the first listed.
NCT03867344 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03867344 about?
NCT03867344 is a clinical study titled "The Functional Neuroanatomy of the Human Physiological Stress Response". The purpose of this study is to examine the effect of a moderately low blood sugar stress on the nervous system. The investigators hope that information obtained from completing this study will help to reveal information about how a non-psychological stress impacts the parts of the brain that react ...
What is the current status of trial NCT03867344?
This trial is currently completed. It is a NA study. The enrollment target is 74 participants. The study started on 2019-10-01. Estimated completion is 2025-12-30.
What interventions are being tested in trial NCT03867344?
The interventions under investigation include: Hypoglycemic Hyperinsulinemic Clamp (OTHER), Normoglycemic Hyperinsulinemic Clamp (OTHER).
Who is sponsoring clinical trial NCT03867344?
This trial is sponsored by Brigham and Women's Hospital, which has 937 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT03867344's enrollment target sits among peer trials
74 1082nd of 2000 higher than 912 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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